Reactome | L protein acts as a cap N7 methyltransferase to modify RSV mRNAs

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L protein acts as a cap N7 methyltransferase to modify RSV mRNAs Show undefined attributes

authored	[InstanceEdit:9830850] Orlic-Milacic, Marija, 2023-03-15
catalystActivity	[CatalystActivity:9834006] mRNA 5'-cap (guanine-N7-)-methyltransferase activity of hRSV A nascent mRNAs:RdRP:p-M2-1 [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9830850] Orlic-Milacic, Marija, 2023-03-15
crossReference	[DatabaseIdentifier:12020771] Mondo:0001577
dbId	9830848
disease	[Disease:9833927] respiratory syncytial virus infectious disease
displayName	L protein acts as a cap N7 methyltransferase to modify RSV mRNAs
edited	[InstanceEdit:9853005] Orlic-Milacic, Marija, 2023-11-09
eventOf	[Pathway:R-HSA-9828642] Respiratory syncytial virus genome transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9834003] L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-RSY-9834004] hRSV A nascent mRNAs:RdRP:p-M2-1 [cytosol] [SimpleEntity:R-ALL-9639461] S-adenosyl-L-methionine [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9833037] Nucleotide sequences of the 1B and 1C nonstructural protein mRNAs of human respiratory syncytial virus [LiteratureReference:9833146] Nucleotide sequence of the gene encoding respiratory syncytial virus matrix protein [LiteratureReference:9829048] Respiratory syncytial virus fusion glycoprotein: nucleotide sequence of mRNA, identification of cleavage activation site and amino acid sequence of N-terminus of F1 subunit [LiteratureReference:9834741] Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase [LiteratureReference:9834866] The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation
maxDepth	1
modified	[InstanceEdit:9853009] Orlic-Milacic, Marija, 2023-11-09
name	L protein acts as a cap N7 methyltransferase to modify RSV mRNAs
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-RSY-9834005] RSV m7GpppG-mRNAs:RdRP:p-M2-1 [cytosol] [SimpleEntity:R-ALL-9639443] S-adenosyl-L-homocysteine [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9828639] Transcription of respiratory syncytial virus subgenomic positive sense mRNAs - Homo sapiens
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9830848
summation	[Summation:9833095] 5' capping of respiratory syncytial virus (RSV) mRNAs is cat...

Referrals

(hasEvent)	[Pathway:R-HSA-9828642] Respiratory syncytial virus genome transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9834003] L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs