Reactome | RdRP binds hRSV nucleocapsid

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RdRP binds hRSV nucleocapsid Show undefined attributes

authored	[InstanceEdit:9833934] Orlic-Milacic, Marija, 2023-05-04
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9833934] Orlic-Milacic, Marija, 2023-05-04
crossReference	[DatabaseIdentifier:12020771] Mondo:0001577
dbId	9833933
disease	[Disease:9833927] respiratory syncytial virus infectious disease
displayName	RdRP binds hRSV nucleocapsid
edited	[InstanceEdit:9853005] Orlic-Milacic, Marija, 2023-11-09
eventOf	[Pathway:R-HSA-9828642] Respiratory syncytial virus genome transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9828639] Transcription of respiratory syncytial virus subgenomic positive sense mRNAs - Homo sapiens
input	[Complex:R-RSY-9825338] hRSV A nucleocapsid [cytosol] [Complex:R-RSY-9830283] RdRP:p-M2-1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9837841] Identification of temperature-sensitive mutations in the phosphoprotein of respiratory syncytial virus that are likely involved in its interaction with the nucleoprotein [LiteratureReference:9838139] Investigation of the Fuzzy Complex between RSV Nucleoprotein and Phosphoprotein to Optimize an Inhibition Assay by Fluorescence Polarization [LiteratureReference:9823510] The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer [LiteratureReference:9838537] Characterization of a viral phosphoprotein binding site on the surface of the respiratory syncytial nucleoprotein [LiteratureReference:9838550] Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein [LiteratureReference:9838553] Identification and characterization of the binding site of the respiratory syncytial virus phosphoprotein to RNA-free nucleoprotein [LiteratureReference:9852904] New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase [LiteratureReference:9825438] Cryo-EM structure of the respiratory syncytial virus RNA polymerase [LiteratureReference:9836779] Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes
maxDepth	1
modified	[InstanceEdit:9853009] Orlic-Milacic, Marija, 2023-11-09
name	RdRP binds hRSV nucleocapsid
output	[Complex:R-RSY-9833931] RdRP:p-M2-1:hRSV A nucleocapsid [cytosol]
precedingEvent	[Reaction:R-HSA-9830284] Protein M2-1 tetramers bind protein P tetramer - Homo sapiens
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9833933
summation	[Summation:9837843] Binding of P protein to N protein enables loading of the RNA...

Referrals

(hasEvent)	[Pathway:R-HSA-9828642] Respiratory syncytial virus genome transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9828639] Transcription of respiratory syncytial virus subgenomic positive sense mRNAs

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