Reactome | M dimer localizes to nucleus

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M dimer localizes to nucleus Show undefined attributes

authored	[InstanceEdit:9831548] Stephan, Ralf, 2023-03-22
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9831676] Stephan, Ralf, 2023-03-24
crossReference	[DatabaseIdentifier:12020771] Mondo:0001577
dbId	9831702
disease	[Disease:9833927] respiratory syncytial virus infectious disease
displayName	M dimer localizes to nucleus
edited	[InstanceEdit:9852992] Stephan, Ralf, 2023-11-09
eventOf	[Pathway:R-HSA-9828806] Maturation of hRSV A proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9831712] M dimer is phosphorylated - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:11054] protein import into nucleus
input	[Complex:R-RSY-9831671] M dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9831685] The matrix protein of Human respiratory syncytial virus localises to the nucleus of infected cells and inhibits transcription [LiteratureReference:9831680] Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha [LiteratureReference:9831672] Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites
maxDepth	1
modified	[InstanceEdit:9939608] Matthews, Lisa, 2025-03-04
name	M dimer localizes to nucleus
output	[Complex:R-RSY-9831694] M dimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9831714] M forms a homodimer - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:9832894] Positive regulation by 'KPNB1 [cytosol]'
regulationReference	[RegulationReference:9832892] Positive regulation by 'KPNB1 [cytosol]' Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03 [InstanceEdit:9939607] Matthews, Lisa, 2025-03-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9831702
summation	[Summation:9831703] Early in hRSV infection, the matrix protein localizes to the...
updateTrackers	[UpdateTracker:9939633] Update Tracker - [BlackBoxEvent:9831702] M dimer localizes to nucleus - v92:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9939633] Update Tracker - [BlackBoxEvent:9831702] M dimer localizes to nucleus - v92:[add_removeRegulator]
(precedingEvent)	[Reaction:R-HSA-9831712] M dimer is phosphorylated
(hasEvent)	[Pathway:R-HSA-9828806] Maturation of hRSV A proteins

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