Reactome | Regulation of TP53 Activity through Association with Co-factors

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Regulation of TP53 Activity through Association with Co-factors Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6804755] Orlic-Milacic, Marija, 2015-10-14
crossReference	[DatabaseIdentifier:12325562] BioModels Database:BIOMD0000000943
dbId	6804759
displayName	Regulation of TP53 Activity through Association with Co-factors
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:9863010] Orlic-Milacic, Marija, 2024-02-26
eventOf	[Pathway:R-HSA-5633007] Regulation of TP53 Activity - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6803425] TP53 binds ZNF385A gene - Homo sapiens [BlackBoxEvent:R-HSA-6803437] TP53 stimulates ZNF385A transcription - Homo sapiens [Reaction:R-HSA-6803719] TP53 binds ZNF385A - Homo sapiens [Reaction:R-HSA-6804402] TP53 binds POU4F1 - Homo sapiens [Reaction:R-HSA-6804425] TP53 binds POU4F2 - Homo sapiens [Reaction:R-HSA-6799761] TP53 binds PPP1R13L - Homo sapiens [Reaction:R-HSA-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Homo sapiens [Reaction:R-HSA-3221982] BANP binds TP53 - Homo sapiens [Reaction:R-HSA-3222259] PHF20 binds TP53 dimethylated on K370 and K382 - Homo sapiens [Reaction:R-HSA-6805785] AKT phosphorylates PHF20 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803710] Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation [LiteratureReference:6804408] Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate [LiteratureReference:6804426] Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression [LiteratureReference:6804428] Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults [LiteratureReference:6804404] p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members [LiteratureReference:6799737] iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human [LiteratureReference:3222257] PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53 [LiteratureReference:8856566] hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes [LiteratureReference:8856564] A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response [LiteratureReference:8856553] Mechanisms of regulatory diversity within the p53 transcriptional network [LiteratureReference:8856552] Transcriptional regulation by p53 [LiteratureReference:6801441] A complex barcode underlies the heterogeneous response of p53 to stress [LiteratureReference:3215145] Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53 [LiteratureReference:8856557] Noncoding RNAs: the missing "linc" in p53-mediated repression
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	Regulation of TP53 Activity through Association with Co-factors
orthologousEvent	[Pathway:R-GGA-6804759] Regulation of TP53 Activity through Association with Co-factors - Gallus gallus [Pathway:R-DRE-6804759] Regulation of TP53 Activity through Association with Co-factors - Danio rerio [Pathway:R-CFA-6804759] Regulation of TP53 Activity through Association with Co-factors - Canis familiaris [Pathway:R-BTA-6804759] Regulation of TP53 Activity through Association with Co-factors - Bos taurus [Pathway:R-SSC-6804759] Regulation of TP53 Activity through Association with Co-factors - Sus scrofa [Pathway:R-XTR-6804759] Regulation of TP53 Activity through Association with Co-factors - Xenopus tropicalis [Pathway:R-DME-6804759] Regulation of TP53 Activity through Association with Co-factors - Drosophila melanogaster [Pathway:R-MMU-6804759] Regulation of TP53 Activity through Association with Co-factors - Mus musculus [Pathway:R-RNO-6804759] Regulation of TP53 Activity through Association with Co-factors - Rattus norvegicus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6804759
summation	[Summation:6806332] Association of TP53 (p53) with various transcriptional co-fa...

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[Pathway:R-HSA-5633007] Regulation of TP53 Activity

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