Frederick Andrew Dick

London Regional Cancer Program, Western University
Reviewed Pathways (5/5)
Date Identifier Pathway Reference
2020-05-17 R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects BibTex
2020-05-17 R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects BibTex
2020-05-17 R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) BibTex
2020-05-17 R-HSA-9661070 Defective translocation of RB1 mutants to the nucleus BibTex
2020-05-17 R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects BibTex
Reviewed Reactions (10/10)
Date Identifier Reaction Reference
2020-05-17 R-HSA-9659782 Defective RB1 does not bind E2F1,(E2F2,E2F3) BibTex
2020-05-17 R-HSA-9660615 Defective RB1 does not translocate to the nucleus BibTex
2020-05-17 R-HSA-9687377 Defective RB1 does not form a complex with SKP2 and FZR1 BibTex
2020-05-17 R-HSA-9018017 RB1 binds and inhibits E2F1/2/3:DP1/2 complexes BibTex
2020-05-17 R-HSA-188390 Cyclin E:CDK2-mediated phosphorylation of RB1 BibTex
2020-05-17 R-HSA-188191 APC/C:Cdh1-mediated degradation of Skp2 BibTex
2020-05-17 R-HSA-9686969 APC/C:Cdh1 polyubiquitinates SKP2 BibTex
2020-05-17 R-HSA-9686980 RB1 recruits APC/C:Cdh1 complex to SKP2 BibTex
2020-05-17 R-HSA-69227 Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes BibTex
2020-05-17 R-HSA-9659820 RB1 translocates to the nucleus BibTex
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