Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Stable Identifier
R-HSA-9661069
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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This pathway describes impaired binding of RB1 pocket domain mutants to activating E2Fs, E2F1, E2F2 and E2F3 (Templeton et al. 1991, Helin et al. 1993, Otterson et al. 1997, Ji et al. 2004).
Literature References
PubMed ID Title Journal Year
9342358 Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function

Kaye, FJ, Otterson, GA, Chen, Wd, Coxon, AB, Khleif, SN

Proc. Natl. Acad. Sci. U.S.A. 1997
15469821 An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant

Ji, P, Rekhtman, K, Pagano, M, Bloom, J, Jiang, H, Zhu, L, Ichetovkin, M

Mol. Cell 2004
8413249 Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

Fattaey, A, Harlow, E, Helin, K

Mol. Cell. Biol. 1993
1826560 Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering

Park, SH, Weinberg, RA, Lanier, L, Templeton, DJ

Proc. Natl. Acad. Sci. U.S.A. 1991
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2020-05-07)
Reviewed
Dick, FA  (2020-05-17)
Created
Orlic-Milacic, M  (2019-09-13)
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