Reactome | APC/C:Cdh1-mediated degradation of Skp2

APC/C:Cdh1-mediated degradation of Skp2

Stable Identifier

R-HSA-188191

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SKP2 is degraded by the anaphase promoting complex/Cyclosome and its activator FZR1 (Cdh1) [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). The tight regulation of APC/C(Cdh1) activity ensures the timely elimination SKP2 and, thus, plays a critical role in controlling the M/G1 transition (mitotic exit). APC/C:Cdh1-mediated degradation of SKP2 depends on RB1, as RB1 recruits SKP2 to the APC/C:Cdh1 complex, by simultaneously interacting with SKP2 and FZR1. RB1 does not undergo APC/C:Cdh1-mediated ubiquitination (Binne et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
15014503	Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex Wei, W, Ayad, NG, Wan, Y, Zhang, GJ, Kirschner, MW, Kaelin WG, Jr	Nature	2004
17187060	Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit Binné, UK, Classon, MK, Dick, FA, Wei, W, Rape, M, Kaelin, WG, Näär, AM, Dyson, NJ	Nat. Cell Biol.	2007