APC/C:Cdh1-mediated degradation of Skp2

Stable Identifier
R-HSA-188191
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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SKP2 is degraded by the anaphase promoting complex/Cyclosome and its activator FZR1 (Cdh1) [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). The tight regulation of APC/C(Cdh1) activity ensures the timely elimination SKP2 and, thus, plays a critical role in controlling the M/G1 transition (mitotic exit). APC/C:Cdh1-mediated degradation of SKP2 depends on RB1, as RB1 recruits SKP2 to the APC/C:Cdh1 complex, by simultaneously interacting with SKP2 and FZR1. RB1 does not undergo APC/C:Cdh1-mediated ubiquitination (Binne et al. 2007).

Literature References
PubMed ID Title Journal Year
17187060 Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

Binné, UK, Classon, MK, Dick, FA, Wei, W, Rape, M, Kaelin, WG, Näär, AM, Dyson, NJ

Nat. Cell Biol. 2007
15014503 Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

Wei, W, Ayad, NG, Wan, Y, Zhang, GJ, Kirschner, MW, Kaelin WG, Jr

Nature 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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