APC/C:Cdh1-mediated degradation of Skp2

Stable Identifier
R-HSA-188191
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Skp2 is degraded by the anaphase promoting complex/Cyclosome and its activator Cdh1 [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). The tight regulation of APC/C(Cdh1) activity ensures the timely elimination Skp2 and, thus, plays a critical role in controlling the G1/S transition.

Literature References
PubMed ID Title Journal Year
15014503 Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

Wei, W, Ayad, NG, Wan, Y, Zhang, GJ, Kirschner, MW, Kaelin WG, Jr

Nature 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created