APC/C:Cdh1-mediated degradation of Skp2

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
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SKP2 is degraded by the anaphase promoting complex/Cyclosome and its activator FZR1 (Cdh1) [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). The tight regulation of APC/C(Cdh1) activity ensures the timely elimination SKP2 and, thus, plays a critical role in controlling the M/G1 transition (mitotic exit). APC/C:Cdh1-mediated degradation of SKP2 depends on RB1, as RB1 recruits SKP2 to the APC/C:Cdh1 complex, by simultaneously interacting with SKP2 and FZR1. RB1 does not undergo APC/C:Cdh1-mediated ubiquitination (Binne et al. 2007).

Literature References
PubMed ID Title Journal Year
15014503 Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

Wan, Y, Kaelin WG, Jr, Kirschner, MW, Zhang, GJ, Wei, W, Ayad, NG

Nature 2004
17187060 Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

Binné, UK, Kaelin, WG, Rape, M, Classon, MK, Wei, W, Dyson, NJ, Dick, FA, Näär, AM

Nat. Cell Biol. 2007
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Orthologous Events
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