Aberrant regulation of mitotic exit in cancer due to RB1 defects

Stable Identifier
R-HSA-9687136
Type
Pathway
Species
Homo sapiens
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RB1 regulates mitotic exit by acting on SKP2, a component of the SCF E3 ubiquitin ligase complex. RB1 facilitates degradation of SKP2 by the anaphase promoting complex/cyclosome (APC/C), thus preventing SKP2-mediated degradation of the cyclin-dependent kinase inhibitor CDKN1B (p27Kip1). RB1-dependent accumulation of p27Kip1 plays an important role in mitotic exit and RB1-mediated tumor suppression (reviewed by Dyson 2016).

Literature References
PubMed ID Title Journal Year
27401552 RB1: a prototype tumor suppressor and an enigma

Dyson, NJ

Genes Dev. 2016
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
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Reviewed
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