Defective translocation of RB1 mutants to the nucleus

Stable Identifier
R-HSA-9661070
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Defective translocation of RB1 mutants to the nucleus
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This pathway describes impaired nuclear localization of RB1 mutants that lack the nuclear localization signal (NLS) (Zacksenhaus et al. 1993, Bremner et al. 1997).
Literature References
PubMed ID Title Journal Year
8336704 A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity

Zacksenhaus, E, Bremner, R, Phillips, RA, Gallie, BL

Mol. Cell. Biol. 1993
9326321 Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma

Bremner, R, Du, DC, Connolly-Wilson, MJ, Bridge, P, Ahmad, KF, Mostachfi, H, Rushlow, D, Dunn, JM, Gallie, BL

Am. J. Hum. Genet. 1997
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
BioModels Database
Authored
Orlic-Milacic, M  (2020-05-07)
Reviewed
Dick, FA  (2020-05-17)
Created
Orlic-Milacic, M  (2019-09-13)
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