Reactome | APC/C:Cdh1 polyubiquitinates SKP2

APC/C:Cdh1 polyubiquitinates SKP2

Stable Identifier

R-HSA-9686969

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RB1-dependent polyubiquitination of SKP2 by the APC/C:Cdh1 complex is an important mechanism of RB1-mediated cell cycle exit, which contributes to the RB1 tumor suppressive role. ABC/C:Cdh1-mediated polyubiquitination targets SKP2 for proteasome-mediated degradation. RB1 and APC/C:Cdh1-dependent degradation of SKP2 allows accumulation of CDKN1B (p27Kip1) in the cell, as CDKN1B is a target of the SKP2-containing SCF ubiquitin ligase complex. CDKN1B acts as a CDK inhibitor, enabling mitotic exit (Ji et al. 2004, Binne et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17187060	Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit Binné, UK, Classon, MK, Dick, FA, Wei, W, Rape, M, Kaelin, WG, Näär, AM, Dyson, NJ	Nat. Cell Biol.	2007