RB1 translocates to the nucleus

Stable Identifier
R-HSA-9659820
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Amino acid residues 860-876 in the C terminal part of RB1 constitute a bipartite nuclear localization signal (NLS), needed for translocation of RB1 from the cytosol to the nucleus. In the absence of the NLS, only a small portion of RB1 translocates to the nucleus, while a large portion of RB1 is retained in the cytosol (Zacksenhaus et al. 1993).

Literature References
PubMed ID Title Journal Year
8336704 A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity

Zacksenhaus, E, Bremner, R, Phillips, RA, Gallie, BL

Mol. Cell. Biol. 1993
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