RB1 translocates to the nucleus

Stable Identifier
R-HSA-9659820
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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RB1 translocates to the nucleus
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Amino acid residues 860-876 in the C terminal part of RB1 constitute a bipartite nuclear localization signal (NLS), needed for translocation of RB1 from the cytosol to the nucleus. In the absence of the NLS, only a small portion of RB1 translocates to the nucleus, while a large portion of RB1 is retained in the cytosol (Zacksenhaus et al. 1993).
Literature References
PubMed ID Title Journal Year
8336704 A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity

Gallie, BL, Zacksenhaus, E, Phillips, RA, Bremner, R

Mol. Cell. Biol. 1993
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Authored
Orlic-Milacic, M  (2017-08-29)
Reviewed
Dick, FA  (2020-05-17)
Created
Orlic-Milacic, M  (2019-09-06)
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