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Akt1 [cytosol]
Stable Identifier
R-RNO-437274
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
KRAC_RAT, Akt1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Mitochondrial unfolded protein response (UPRmt) (Rattus norvegicus)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-inhibition by CTLA4 (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
Akt [cytosol] (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
Co-stimulation by CD28 (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
PIP3 recruits AKT to the membrane (Rattus norvegicus)
Akt [cytosol] (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
PIP3 recruits AKT to the membrane (Rattus norvegicus)
Akt [cytosol] (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G-protein beta:gamma signalling (Rattus norvegicus)
G beta:gamma signalling through PI3Kgamma (Rattus norvegicus)
PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)
Akt [cytosol] (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
Signaling by Non-Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PTK6 (Rattus norvegicus)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Rattus norvegicus)
PTK6 binds AKT1 (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
p-Y342-PTK6:AKT1 [cytosol] (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
PTK6 phosphorylates AKT1 (Rattus norvegicus)
p-Y342-PTK6:AKT1 [cytosol] (Rattus norvegicus)
Akt1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P47196 Akt1
Gene Names
Akt1
Chain
chain:1-480
Reference Genes
BioGPS Gene:24185 Akt1
KEGG:rno:24185 Akt1
Monarch:24185 Akt1
NCBI Gene:24185 Akt1
UCSC:P47196 Akt1
Reference Transcript
RefSeq:NM_033230.2 Akt1
RefSeq:XM_006240631.2 Akt1
Participates
as an input of
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Rattus norvegicus)
PTK6 binds AKT1 (Rattus norvegicus)
as a component of
p-Y342-PTK6:AKT1 [cytosol] (Rattus norvegicus)
as an output of
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
as a member of
Akt [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [plasma membrane]
phospho-p-Y315,Y326-AKT1 [cytosol]
phospho-p-T308-AKT1 [cytosol]
Phospho-Akt1 [nucleoplasm]
Phospho-Akt1 [cytosol]
AKT1 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-T308,S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [nucleoplasm]
Inferred From
AKT1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_150233.1
,
XP_006240693.1
IntEnz
2.7.11.1
PRO
P47196
GlyGen
P47196
RGD
2081
HMDB Protein
HMDBP13421
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63369 NFKB1
0.61
9
UniProt:P84025
9
Ub-SMAD3 [cytosol]
(R-RNO-6782830)
phospho-p-S208-SMAD3 [cytosol]
(R-RNO-9731114)
SMAD3 [nucleoplasm]
(R-RNO-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2176471)
SMAD3 [cytosol]
(R-RNO-170855)
phospho-p-S423,S425-SMAD3 [cytosol]
(R-RNO-171184)
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-177104)
0.524
4
UniProt:O70436
8
Ub-SMAD2 [cytosol]
(R-RNO-6782774)
phospho-p-S250-SMAD2 [cytosol]
(R-RNO-9731121)
SMAD2 [nucleoplasm]
(R-RNO-3006352)
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-9773843)
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009189)
SMAD2 [cytosol]
(R-RNO-3006353)
phospho-p-S465,S467-SMAD2 [cytosol]
(R-RNO-3009186)
phospho-p-S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009185)
0.524
2
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