Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-S473-AKT1 [plasma membrane]
Stable Identifier
R-RNO-377265
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
P47196
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Rattus norvegicus)
mTORC2 phosphorylates AKT1 on serine-473 (Rattus norvegicus)
p-S473-AKT1:PIP3 [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
p-T816-PKN2 phosphorylates AKT1 on serine-308 (Rattus norvegicus)
p-S473-AKT1:PIP3 [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-stimulation by CD28 (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT [plasma membrane] (Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P47196 Akt1
Gene Names
Akt1
Chain
chain:1-480
Reference Genes
BioGPS Gene:24185 Akt1
KEGG:rno:24185 Akt1
Monarch:24185 Akt1
NCBI Gene:24185 Akt1
UCSC:P47196 Akt1
Reference Transcript
RefSeq:NM_033230.2 Akt1
RefSeq:XM_006240631.2 Akt1
Participates
as a component of
p-S473-AKT1:PIP3 [plasma membrane] (Rattus norvegicus)
as a member of
p-S-AKT [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [plasma membrane]
phospho-p-Y315,Y326-AKT1 [cytosol]
phospho-p-T308-AKT1 [cytosol]
Phospho-Akt1 [nucleoplasm]
Phospho-Akt1 [cytosol]
Akt1 [cytosol]
AKT1 [plasma membrane]
phospho-p-T308,S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [nucleoplasm]
Inferred From
p-S473-AKT1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_150233.1
,
XP_006240693.1
IntEnz
2.7.11.1
PRO
P47196
GlyGen
P47196
RGD
2081
HMDB Protein
HMDBP13421
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63369 NFKB1
0.61
9
UniProt:P84025
9
Ub-SMAD3 [cytosol]
(R-RNO-6782830)
phospho-p-S208-SMAD3 [cytosol]
(R-RNO-9731114)
SMAD3 [nucleoplasm]
(R-RNO-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2176471)
SMAD3 [cytosol]
(R-RNO-170855)
phospho-p-S423,S425-SMAD3 [cytosol]
(R-RNO-171184)
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-177104)
0.524
4
UniProt:O70436
8
Ub-SMAD2 [cytosol]
(R-RNO-6782774)
phospho-p-S250-SMAD2 [cytosol]
(R-RNO-9731121)
SMAD2 [nucleoplasm]
(R-RNO-3006352)
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-9773843)
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009189)
SMAD2 [cytosol]
(R-RNO-3006353)
phospho-p-S465,S467-SMAD2 [cytosol]
(R-RNO-3009186)
phospho-p-S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009185)
0.524
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text