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phospho-p-S465,S467-SMAD2 [cytosol]
Stable Identifier
R-RNO-3009186
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
O70436
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Signaling by NODAL (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by Activin (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
TGF-beta receptor signaling activates SMADs (Rattus norvegicus)
Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Downregulation of TGF-beta receptor signaling (Rattus norvegicus)
MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S465,S467-SMAD2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O70436
Reference Genes
BioGPS Gene:29357
ENSEMBL:ENSRNOG00000008620
ENSEMBL:ENSRNOG00000018140
ENSEMBL:ENSRNOG00055013852
ENSEMBL:ENSRNOG00060010583
ENSEMBL:ENSRNOG00065022764
KEGG:rno:29357
Monarch:29357
NCBI Gene:29357
UCSC:O70436
Reference Transcript
RefSeq:NM_019191.2
RefSeq:NM_001277450.1
Other Identifiers
10802741
1368214_at
17724325
29357
5634140
5666069
5742059
5790733
5830125
5850315
5877677
5956840
5961567
5972038
5979658
6138478
6188890
6207143
6271879
6287619
6393800
6440808
6502694
6565834
6598215
6621764
6648233
6689851
6741308
AB017912_at
AB017912_g_at
A_44_P210520
GE20574
GO:0000785
GO:0000978
GO:0001228
GO:0001657
GO:0001701
GO:0001706
GO:0001707
GO:0003140
GO:0003180
GO:0003184
GO:0003203
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005634
GO:0005667
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0007179
GO:0007352
GO:0007369
GO:0007389
GO:0007492
GO:0007507
GO:0008092
GO:0009749
GO:0009791
GO:0009880
GO:0009952
GO:0010628
GO:0010629
GO:0010718
GO:0017015
GO:0019902
GO:0023052
GO:0030073
GO:0030154
GO:0030324
GO:0030513
GO:0031016
GO:0031625
GO:0032444
GO:0032924
GO:0032991
GO:0034713
GO:0035265
GO:0035556
GO:0038092
GO:0042802
GO:0043226
GO:0045165
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0048156
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0060039
GO:0060395
GO:0061629
GO:0062009
GO:0070410
GO:0070411
GO:0070412
GO:0070723
GO:0071141
GO:0071142
GO:0071144
GO:0071895
GO:0097718
GO:0140110
GO:0140297
ILMN_1360346
PH_rn_0002482
rc_AI105449_at
rc_AI228675_at
Participates
as a member of
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
as a component of
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Rattus norvegicus)
Other forms of this molecule
Ub-SMAD2 [cytosol]
phospho-p-S250-SMAD2 [cytosol]
SMAD2 [nucleoplasm]
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
SMAD2 [cytosol]
phospho-p-S465,S467-SMAD2 [nucleoplasm]
Inferred From
p-S465,S467-SMAD2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 465 (in Homo sapiens)
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 467 (in Homo sapiens)
Coordinate
467
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001264379.1
,
NP_062064.1
ENSEMBL
ENSRNOP00000075341
,
ENSRNOT00000092173
PRO
O70436
RGD
3031
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P47196 Akt1
11
phospho-p-S473-AKT1 [cytosol]
(R-RNO-9841264)
phospho-p-T308,S473-AKT1 [plasma membrane]
(R-RNO-199430)
phospho-p-Y315,Y326-AKT1 [cytosol]
(R-RNO-8848757)
phospho-p-T308-AKT1 [cytosol]
(R-RNO-198634)
Phospho-Akt1 [nucleoplasm]
(R-RNO-198325)
Phospho-Akt1 [cytosol]
(R-RNO-198376)
Akt1 [cytosol]
(R-RNO-437274)
AKT1 [plasma membrane]
(R-RNO-199416)
phospho-p-S473-AKT1 [plasma membrane]
(R-RNO-377265)
phospho-p-T308,S473-AKT1 [cytosol]
(R-RNO-198356)
phospho-p-T308,S473-AKT1 [nucleoplasm]
(R-RNO-198357)
0.524
2
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