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phospho-p-T308,S473-AKT1 [plasma membrane]
Stable Identifier
R-RNO-199430
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
P47196
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Rattus norvegicus)
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Rattus norvegicus)
p-T308,S473-AKT1:PIP3 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
p-T816-PKN2 phosphorylates AKT1 on serine-308 (Rattus norvegicus)
p-T308,S473-AKT1:PIP3 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)
AKT1/PDK1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
eNOS activation (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)
AKT1/PDK1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
MTOR signalling (Rattus norvegicus)
Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P47196 Akt1
Gene Names
Akt1
Chain
chain:1-480
Reference Genes
BioGPS Gene:24185 Akt1
KEGG:rno:24185 Akt1
Monarch:24185 Akt1
NCBI Gene:24185 Akt1
UCSC:P47196 Akt1
Reference Transcript
RefSeq:NM_033230.2 Akt1
RefSeq:XM_006240631.2 Akt1
Participates
as a member of
AKT1/PDK1 [plasma membrane] (Rattus norvegicus)
as a component of
p-T308,S473-AKT1:PIP3 [plasma membrane] (Rattus norvegicus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-p-Y315,Y326-AKT1 [cytosol]
phospho-p-T308-AKT1 [cytosol]
Phospho-Akt1 [nucleoplasm]
Phospho-Akt1 [cytosol]
Akt1 [cytosol]
AKT1 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-T308,S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [nucleoplasm]
Inferred From
p-T308,S473-AKT1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_150233.1
,
XP_006240693.1
IntEnz
2.7.11.1
PRO
P47196
GlyGen
P47196
RGD
2081
HMDB Protein
HMDBP13421
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63369 NFKB1
0.61
9
UniProt:P84025
9
Ub-SMAD3 [cytosol]
(R-RNO-6782830)
phospho-p-S208-SMAD3 [cytosol]
(R-RNO-9731114)
SMAD3 [nucleoplasm]
(R-RNO-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2176471)
SMAD3 [cytosol]
(R-RNO-170855)
phospho-p-S423,S425-SMAD3 [cytosol]
(R-RNO-171184)
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-177104)
0.524
4
UniProt:O70436
8
Ub-SMAD2 [cytosol]
(R-RNO-6782774)
phospho-p-S250-SMAD2 [cytosol]
(R-RNO-9731121)
SMAD2 [nucleoplasm]
(R-RNO-3006352)
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-9773843)
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009189)
SMAD2 [cytosol]
(R-RNO-3006353)
phospho-p-S465,S467-SMAD2 [cytosol]
(R-RNO-3009186)
phospho-p-S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009185)
0.524
2
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