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phospho-p-T308,S473-AKT1 [nucleoplasm]
Stable Identifier
R-RNO-198357
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
P47196
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Regulation of beta-cell development (Rattus norvegicus)
Regulation of gene expression in beta cells (Rattus norvegicus)
AKT-mediated inactivation of FOXO1A (Rattus norvegicus)
AKT phosphorylates FOXO1A (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
FOXO-mediated transcription (Rattus norvegicus)
Regulation of localization of FOXO transcription factors (Rattus norvegicus)
AKT phosphorylates FOXO transcription factors (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Activity through Acetylation (Rattus norvegicus)
AKT phosphorylates KAT6A (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
KAT6A and PML bind TP53 (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Activity through Association with Co-factors (Rattus norvegicus)
AKT phosphorylates PHF20 (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
FLT3 Signaling (Rattus norvegicus)
AKT phosphorylates FOXO3 downstream of FLT3 (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
AKT phosphorylates targets in the nucleus (Rattus norvegicus)
AKT can phosphorylate NR4A1 (NUR77) (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
AKT can phosphorylate RSK (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
AKT phosphorylates CREB1 (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
AKT phosphorylates FOXO transcription factors (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Rattus norvegicus)
AKT phosphorylates CREB1 (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Deactivation of the beta-catenin transactivating complex (Rattus norvegicus)
AKT phosphorylates CBY1 (Rattus norvegicus)
p-AKT1/2 [nucleoplasm] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P47196 Akt1
Gene Names
Akt1
Chain
chain:1-480
Reference Genes
BioGPS Gene:24185 Akt1
KEGG:rno:24185 Akt1
Monarch:24185 Akt1
NCBI Gene:24185 Akt1
UCSC:P47196 Akt1
Reference Transcript
RefSeq:NM_033230.2 Akt1
RefSeq:XM_006240631.2 Akt1
Participates
as a member of
p-AKT1/2 [nucleoplasm] (Rattus norvegicus)
p-T,p-S-AKT [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [plasma membrane]
phospho-p-Y315,Y326-AKT1 [cytosol]
phospho-p-T308-AKT1 [cytosol]
Phospho-Akt1 [nucleoplasm]
Phospho-Akt1 [cytosol]
Akt1 [cytosol]
AKT1 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-T308,S473-AKT1 [cytosol]
Inferred From
p-T308,S473-AKT1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_150233.1
,
XP_006240693.1
IntEnz
2.7.11.1
PRO
P47196
GlyGen
P47196
RGD
2081
HMDB Protein
HMDBP13421
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63369 NFKB1
0.61
9
UniProt:P84025
9
Ub-SMAD3 [cytosol]
(R-RNO-6782830)
phospho-p-S208-SMAD3 [cytosol]
(R-RNO-9731114)
SMAD3 [nucleoplasm]
(R-RNO-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2176471)
SMAD3 [cytosol]
(R-RNO-170855)
phospho-p-S423,S425-SMAD3 [cytosol]
(R-RNO-171184)
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-177104)
0.524
4
UniProt:O70436
8
Ub-SMAD2 [cytosol]
(R-RNO-6782774)
phospho-p-S250-SMAD2 [cytosol]
(R-RNO-9731121)
SMAD2 [nucleoplasm]
(R-RNO-3006352)
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-9773843)
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009189)
SMAD2 [cytosol]
(R-RNO-3006353)
phospho-p-S465,S467-SMAD2 [cytosol]
(R-RNO-3009186)
phospho-p-S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009185)
0.524
2
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