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phospho-p-S423,S425-SMAD3 [cytosol]
Stable Identifier
R-RNO-171184
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P84025
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Signaling by NODAL (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by Activin (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
TGF-beta receptor signaling activates SMADs (Rattus norvegicus)
Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Downregulation of TGF-beta receptor signaling (Rattus norvegicus)
MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
phospho-p-S423,S425-SMAD3 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P84025
Reference Genes
BioGPS Gene:25631
ENSEMBL:ENSRNOG00000008620
ENSEMBL:ENSRNOG00055023531
ENSEMBL:ENSRNOG00060018232
ENSEMBL:ENSRNOG00065007937
KEGG:rno:25631
Monarch:25631
NCBI Gene:25631
UCSC:P84025
Reference Transcript
RefSeq:NM_013095.3
Other Identifiers
10918169
1369528_at
17853397
25631
5643881
5645953
5651645
5733832
5892278
5900495
5924083
5933537
5993401
6036693
6106795
6133269
6141641
6143418
6180712
6266112
6295939
6359733
6421015
6511307
6515797
6652449
6669833
6672587
6720065
6746921
A_44_P531593
A_64_P068167
GE1130191
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001217
GO:0001222
GO:0001223
GO:0001228
GO:0001501
GO:0001649
GO:0001657
GO:0001666
GO:0001701
GO:0001707
GO:0001756
GO:0001889
GO:0001947
GO:0002076
GO:0002376
GO:0002520
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005518
GO:0005634
GO:0005635
GO:0005637
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0006955
GO:0007179
GO:0007254
GO:0007369
GO:0007492
GO:0008270
GO:0008285
GO:0009880
GO:0010628
GO:0010629
GO:0010718
GO:0012501
GO:0016202
GO:0016922
GO:0017015
GO:0017151
GO:0019901
GO:0019902
GO:0023052
GO:0030154
GO:0030198
GO:0030308
GO:0030878
GO:0031490
GO:0031625
GO:0031962
GO:0032332
GO:0032810
GO:0032909
GO:0032924
GO:0033689
GO:0034330
GO:0035259
GO:0038092
GO:0042060
GO:0042110
GO:0042802
GO:0042803
GO:0043130
GO:0043226
GO:0043235
GO:0043425
GO:0043565
GO:0045216
GO:0045429
GO:0045599
GO:0045668
GO:0045893
GO:0045944
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0050678
GO:0050728
GO:0050776
GO:0051481
GO:0060039
GO:0060395
GO:0061045
GO:0061629
GO:0070306
GO:0070410
GO:0070412
GO:0071141
GO:0071144
GO:0071560
GO:0097191
GO:0098586
GO:0140110
GO:0140297
GO:1901203
GO:1902894
GO:1902895
GO:1990776
GO:1990841
ILMN_1354074
PH_rn_0010998
U66479_at
Participates
as a member of
p-2S-SMAD2,3 [cytosol] (Rattus norvegicus)
as a component of
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Rattus norvegicus)
Other forms of this molecule
Ub-SMAD3 [cytosol]
phospho-p-S208-SMAD3 [cytosol]
SMAD3 [nucleoplasm]
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
SMAD3 [cytosol]
phospho-p-S423,S425-SMAD3 [nucleoplasm]
Inferred From
p-S423,S425-SMAD3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 423 (in Homo sapiens)
Coordinate
423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 425 (in Homo sapiens)
Coordinate
425
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_037227.1
ENSEMBL
ENSRNOT00000039730
,
ENSRNOP00000037346
PRO
P84025
RGD
3032
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.524
4
UniProt:P47196 Akt1
11
phospho-p-S473-AKT1 [cytosol]
(R-RNO-9841264)
phospho-p-T308,S473-AKT1 [plasma membrane]
(R-RNO-199430)
phospho-p-Y315,Y326-AKT1 [cytosol]
(R-RNO-8848757)
phospho-p-T308-AKT1 [cytosol]
(R-RNO-198634)
Phospho-Akt1 [nucleoplasm]
(R-RNO-198325)
Phospho-Akt1 [cytosol]
(R-RNO-198376)
Akt1 [cytosol]
(R-RNO-437274)
AKT1 [plasma membrane]
(R-RNO-199416)
phospho-p-S473-AKT1 [plasma membrane]
(R-RNO-377265)
phospho-p-T308,S473-AKT1 [cytosol]
(R-RNO-198356)
phospho-p-T308,S473-AKT1 [nucleoplasm]
(R-RNO-198357)
0.524
4
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