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phospho-p-T308,S473-AKT1 [cytosol]
Stable Identifier
R-RNO-198356
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P47196
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G1/S Transition (Rattus norvegicus)
Cyclin E associated events during G1/S transition (Rattus norvegicus)
AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
S Phase (Rattus norvegicus)
Cyclin A:Cdk2-associated events at S phase entry (Rattus norvegicus)
AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
NFE2L2 translocates from cytosol to nucleoplasm (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
AKT phosphorylates MDM2 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-inhibition by CTLA4 (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Co-stimulation by CD28 (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
AKT interacts and phosphorylates Cot (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
eNOS activation (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Metabolism of RNA (Rattus norvegicus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Rattus norvegicus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Rattus norvegicus)
Protein Kinase B/Akt phosphorylates BRF1 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
KSRP (KHSRP) binds and destabilizes mRNA (Rattus norvegicus)
Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
AKT phosphorylates targets in the cytosol (Rattus norvegicus)
AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates IKKalpha (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates MDM2 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates MKRN1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates caspase-9 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN stability and activity (Rattus norvegicus)
AKT phosphorylates MKRN1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by NOTCH (Rattus norvegicus)
Signaling by NOTCH4 (Rattus norvegicus)
Negative regulation of NOTCH4 signaling (Rattus norvegicus)
AKT1 phosphorylates NOTCH4 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
Downregulation of ERBB2 signaling (Rattus norvegicus)
Downregulation of ERBB2:ERBB3 signaling (Rattus norvegicus)
Phosphorylation of USP8 by P-AKT (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Rab regulation of trafficking (Rattus norvegicus)
RAB GEFs exchange GTP for GDP on RABs (Rattus norvegicus)
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P47196 Akt1
Gene Names
Akt1
Chain
chain:1-480
Reference Genes
BioGPS Gene:24185 Akt1
KEGG:rno:24185 Akt1
Monarch:24185 Akt1
NCBI Gene:24185 Akt1
UCSC:P47196 Akt1
Reference Transcript
RefSeq:NM_033230.2 Akt1
RefSeq:XM_006240631.2 Akt1
Participates
as an input of
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
as a component of
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
as a member of
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [plasma membrane]
phospho-p-Y315,Y326-AKT1 [cytosol]
phospho-p-T308-AKT1 [cytosol]
Phospho-Akt1 [nucleoplasm]
Phospho-Akt1 [cytosol]
Akt1 [cytosol]
AKT1 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-T308,S473-AKT1 [nucleoplasm]
Inferred From
p-T308,S473-AKT1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_150233.1
,
XP_006240693.1
IntEnz
2.7.11.1
PRO
P47196
GlyGen
P47196
RGD
2081
HMDB Protein
HMDBP13421
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63369 NFKB1
0.61
9
UniProt:P84025
9
Ub-SMAD3 [cytosol]
(R-RNO-6782830)
phospho-p-S208-SMAD3 [cytosol]
(R-RNO-9731114)
SMAD3 [nucleoplasm]
(R-RNO-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2176471)
SMAD3 [cytosol]
(R-RNO-170855)
phospho-p-S423,S425-SMAD3 [cytosol]
(R-RNO-171184)
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-177104)
0.524
4
UniProt:O70436
8
Ub-SMAD2 [cytosol]
(R-RNO-6782774)
phospho-p-S250-SMAD2 [cytosol]
(R-RNO-9731121)
SMAD2 [nucleoplasm]
(R-RNO-3006352)
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-9773843)
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009189)
SMAD2 [cytosol]
(R-RNO-3006353)
phospho-p-S465,S467-SMAD2 [cytosol]
(R-RNO-3009186)
phospho-p-S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009185)
0.524
2
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