Reactome | DAD1 [endoplasmic reticulum membrane]

DAD1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-265089

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Dad1

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
        
        CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST Subcomplex III [endoplasmic reticulum membrane] (Homo sapiens)
        
        DAD1 [endoplasmic reticulum membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        CD274 N-linked glycosylation in ER (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST Subcomplex III [endoplasmic reticulum membrane] (Homo sapiens)
        
        DAD1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST Subcomplex III [endoplasmic reticulum membrane] (Homo sapiens)
        
        DAD1 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61803 DAD1

Gene Names

DAD1

Chain

initiator methionine:1, chain:2-113

Reference Genes

BioGPS Gene:1603 DAD1

COSMIC - genes:DAD1 DAD1

CTD Gene:1603 DAD1

dbSNP Gene:1603 DAD1

ENSEMBL:ENSG00000129562 DAD1

HGNC:2664 DAD1

KEGG:hsa:1603 DAD1

Monarch:1603 DAD1

NCBI Gene:1603 DAD1

OMIM:600243 DAD1

UCSC:P61803 DAD1

Reference Transcript

RefSeq:NM_001344.4 DAD1

Other Identifiers

11720317_a_at

11754060_a_at

11757687_x_at

1603

16655387

16655389

16655391

16655393

16655395

16655397

16655399

16655401

16655403

16790464

18671151

18671152

18671153

18671154

18671155

18671157

18671158

200046_PM_at

200046_at

3556570

3556571

3556572

3556573

3556574

3556577

3556578

3556579

3556580

3556581

3556588

3556589

3556590

3556654

3556656

3556658

3556660

3556662

3556668

3556670

3556672

3556674

3556676

3556678

3556680

3556682

3556684

3556686

3556688

38413_at

7892522

7892653

7892654

7892663

7892704

7892958

7893844

7893962

7894415

7894576

7894692

7895007

7895236

7895246

7895462

7895746

7896116

7896229

7896402

7896502

7896653

7977775

A_23_P106056

A_24_P47870

A_24_P56462

D15057_at

GE79876

GO:0001824

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0006915

GO:0008047

GO:0008250

GO:0016020

GO:0018279

GO:0031647

GO:0043066

GO:0048856

GO:0098772

GO:0160226

GO:0160227

HMNXSV003012164

ILMN_1731619

PH_hs_0004740

TC14000931.hg

g4503252_3p_s_at

Participates

as a component of

OST Subcomplex III [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Dad1 [endoplasmic reticulum membrane] (Mus musculus)

Dad1 [endoplasmic reticulum membrane] (Rattus norvegicus)

DAD1 [endoplasmic reticulum membrane] (Bos taurus)

DAD1 [endoplasmic reticulum membrane] (Canis familiaris)

DAD1 [endoplasmic reticulum membrane] (Gallus gallus)

DAD1 [endoplasmic reticulum membrane] (Sus scrofa)

dad1 [endoplasmic reticulum membrane] (Danio rerio)

dad1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001335.1

ENSEMBL

ENSP00000250498, ENSG00000129562, ENST00000250498

OpenTargets

ENSG00000129562

GeneCards

DAD1

HPA

ENSG00000129562-DAD1

PRO

P61803

Pharos - Targets

P61803

GlyGen

P61803

HMDB Protein

HMDBP03268

PDB

6S7T, 6S7O, 8PN9, 8B6L

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TCJ2 STT3B	1	STT3B [endoplasmic reticulum membrane] (R-HSA-264930)	0.528	2
UniProt:Q14165 MLEC	3	MLEC [plasma membrane] (R-HSA-6806292) MLEC [specific granule membrane] (R-HSA-6799618) MLEC [endoplasmic reticulum membrane] (R-HSA-901082)	0.528	2
UniProt:P23945 FSHR	1	FSHR [plasma membrane] (R-HSA-391380)	0.527	2
UniProt:Q13454 TUSC3	2	TUSC3 [endoplasmic reticulum membrane] (R-HSA-9932255) TUSC3(1-348) [plasma membrane] (R-HSA-5339529)	0.527	2
UniProt:Q9H0U3 MAGT1	3	MAGT1 [plasma membrane] (R-HSA-4836523) MAGT1 [azurophil granule membrane] (R-HSA-6799208) MAGT1 [endoplasmic reticulum membrane] (R-HSA-9932187)	0.527	2

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