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Sphingolipid catabolism
Stable Identifier
R-HSA-9845614
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
,
endoplasmic reticulum membrane
,
Golgi lumen
,
Golgi membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid catabolism (Homo sapiens)
General
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The main steps involved in de novo sphingolipid synthesis are annotated here (Gault et al. 2010).
Literature References
PubMed ID
Title
Journal
Year
20919643
An overview of sphingolipid metabolism: from synthesis to breakdown
Gault, CR
,
Hannun, YA
,
Obeid, LM
Adv Exp Med Biol
2010
Participants
Events
ACER1 hydrolyzes ceramide (endoplasmic reticulum)
(Homo sapiens)
ACER2 hydrolyzes ceramide (Golgi)
(Homo sapiens)
ACER3 hydrolyzes phytoceramide
(Homo sapiens)
SGPP1,2 dephosphorylate sphingoid-1-phosphates
(Homo sapiens)
PXLP-SGPL1 cleaves sphingoid-1-phosphates
(Homo sapiens)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate
(Homo sapiens)
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate
(Homo sapiens)
ALDH3A2-1 oxidises HD2NAL to PALM
(Homo sapiens)
ALDH3B1 oxidises HXAL to PALM
(Homo sapiens)
ALDH3B2 oxidises HXAL to PALM
(Homo sapiens)
Participates
as an event of
Sphingolipid metabolism (Homo sapiens)
Event Information
Go Biological Process
sphingolipid catabolic process (0030149)
Orthologous Events
Sphingolipid catabolism (Bos taurus)
Sphingolipid catabolism (Caenorhabditis elegans)
Sphingolipid catabolism (Canis familiaris)
Sphingolipid catabolism (Danio rerio)
Sphingolipid catabolism (Dictyostelium discoideum)
Sphingolipid catabolism (Drosophila melanogaster)
Sphingolipid catabolism (Gallus gallus)
Sphingolipid catabolism (Mus musculus)
Sphingolipid catabolism (Rattus norvegicus)
Sphingolipid catabolism (Saccharomyces cerevisiae)
Sphingolipid catabolism (Schizosaccharomyces pombe)
Sphingolipid catabolism (Sus scrofa)
Sphingolipid catabolism (Xenopus tropicalis)
Authored
Stephan, R (2023-10-05)
Reviewed
D'Eustachio, P (2023-10-24)
Created
Stephan, R (2023-10-06)
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