ACER2 hydrolyzes ceramide (Golgi)

Stable Identifier
Reaction [transition]
Homo sapiens
ceramide + H2O => fatty acid + sphingosine (Golgi)
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ACER2 (alkaline ceramidase 2), associated with the membrane of the Golgi apparatus, catalyzes the hydrolysis of ceramide to yield a free fatty acid and sphingosine. ACER2 hydrolyses ceramides and dihydroceramides C18:1 and C20:1 (Casasampere et al., 2015). ACER2 mRNA is widely expressed in the body, although only at low levels except in the placenta (Xu et al., 2006; Sun et al., 2010; Xu et al., 2018). ACER2 expression is regulated by the tumor suppressor p53 and endothelial PAS domain-containing protein 1 (EPAS1, hypoxia-inducible factor HIF2A) (reviewed by Mao & Obeid, 2008; Parveen et al., 2019; Duarte et al., 2020).

Literature References
PubMed ID Title Journal Year
29229990 Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2

Mao, C, Li, F, Garcia-Barros, M, Wen, S, Xu, R, Hannun, YA, Obeid, LM, Lin, CL

Cell Death Differ 2018
16940153 Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

Mao, C, Sun, W, Hu, W, Jin, J, Taha, T, Bielawski, J, Xu, R, Obeid, LM, Szulc, ZM

FASEB J 2006
26286360 Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols

Egido-Gabás, M, Casas, J, Canals, D, Camacho, L, Bedia, C, Fabrias, G, Wang, K, Mao, C, Cingolani, F, Casasampere, M, Xu, R, Abad, JL, Hannun, YA

J Lipid Res 2015
31817238 Role of Ceramidases in Sphingolipid Metabolism and Human Diseases

Mishra, VK, Bender, D, Law, SH, Chen, CC, Ke, LY, Parveen, F

Cells 2019
20089856 Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

Mao, C, Sun, W, Hu, W, Jin, J, Bielawski, J, Xu, R, Obeid, LM, Szulc, ZM

J Biol Chem 2010
18619555 Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

Mao, C, Obeid, LM

Biochim Biophys Acta 2008
32498325 Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration

Mao, C, Yamada, C, Movila, A, Ho, A, Akkaoui, J, Duarte, C

Cells 2020
Catalyst Activity

N-acylsphingosine amidohydrolase activity of ACER2 [Golgi membrane]

Orthologous Events
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