Reactome | ACER2 hydrolyzes ceramide (Golgi)

ACER2 hydrolyzes ceramide (Golgi)

Stable Identifier

R-HSA-428205

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

Synonyms

ceramide + H2O => fatty acid + sphingosine (Golgi)

ReviewStatus

5/5

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ACER2 (alkaline ceramidase 2), associated with the membrane of the Golgi apparatus, catalyzes the hydrolysis of ceramide to yield a free fatty acid and sphingosine. ACER2 hydrolyses ceramides and dihydroceramides C18:1 and C20:1 (Casasampere et al., 2015). ACER2 mRNA is widely expressed in the body, although only at low levels except in the placenta (Xu et al., 2006; Sun et al., 2010; Xu et al., 2018). ACER2 expression is regulated by the tumor suppressor p53 and endothelial PAS domain-containing protein 1 (EPAS1, hypoxia-inducible factor HIF2A) (reviewed by Mao & Obeid, 2008; Parveen et al., 2019; Duarte et al., 2020).

Literature References

PubMed ID	Title	Journal	Year
29229990	Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 Mao, C, Li, F, Garcia-Barros, M, Wen, S, Xu, R, Hannun, YA, Obeid, LM, Lin, CL	Cell Death Differ	2018
16940153	Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P Mao, C, Sun, W, Hu, W, Jin, J, Taha, T, Bielawski, J, Xu, R, Obeid, LM, Szulc, ZM	FASEB J	2006
26286360	Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols Egido-Gabás, M, Casas, J, Canals, D, Camacho, L, Bedia, C, Fabrias, G, Wang, K, Mao, C, Cingolani, F, Casasampere, M, Xu, R, Abad, JL, Hannun, YA	J Lipid Res	2015
31817238	Role of Ceramidases in Sphingolipid Metabolism and Human Diseases Mishra, VK, Bender, D, Law, SH, Chen, CC, Ke, LY, Parveen, F	Cells	2019
20089856	Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2) Mao, C, Sun, W, Hu, W, Jin, J, Bielawski, J, Xu, R, Obeid, LM, Szulc, ZM	J Biol Chem	2010
18619555	Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate Mao, C, Obeid, LM	Biochim Biophys Acta	2008
32498325	Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration Mao, C, Yamada, C, Movila, A, Ho, A, Akkaoui, J, Duarte, C	Cells	2020