ACER3 (alkaline ceramidase 3) catalyzes the hydrolysis of phytoceramide to yield a free fatty acid (annotated here as stearate) and phytosphingosine. ACER3 mRNA is widely expressed in the body, although most abundant in placenta. Immunofluoresence studies of cultured cells over-expressing GFP-tagged protein suggest its localization to membranes of the endoplasmic reticulum (annotated here) and also the Golgi apparatus (Mao et al. 2001).
Mao, C, Xu, R, Obeid, LM, Bielawska, A, Galadari, SH, Szulc, ZM
phytoceramidase activity of ACER3 [endoplasmic reticulum membrane]
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