Reactome | phytoceramide + H2O => stearate + phytosphingosine

phytoceramide + H2O => stearate + phytosphingosine

Stable Identifier

R-HSA-428262

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

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phytoceramide + H2O => stearate + phytosphingosine

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ACER3 (alkaline ceramidase 3) catalyzes the hydrolysis of phytoceramide to yield a free fatty acid (annotated here as stearate) and phytosphingosine. ACER3 mRNA is widely expressed in the body, although most abundant in placenta. Immunofluoresence studies of cultured cells over-expressing GFP-tagged protein suggest its localization to membranes of the endoplasmic reticulum (annotated here) and also the Golgi apparatus (Mao et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11356846	Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide Mao, C, Xu, R, Szulc, ZM, Bielawska, A, Galadari, SH, Obeid, LM	J Biol Chem	2001