Reactome | ALDH3B1 oxidises HXAL to PALM

ALDH3B1 oxidises HXAL to PALM

Stable Identifier

R-HSA-5696080

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Aldehyde dehydrogenases (ALDHs) detoxify toxic aldehydes by oxidation to the corresponding carboxylic acids. Long-chain aliphatic aldehydes are largely produced by catabolic metabolism of several lipids, including ether glycerolipids, fatty alcohols, sphingolipids and wax esters. Some medium-chain aliphatic aldehydes, such as hexanal, octanal and 4-hydroxy-2-nonenal (4HNE) are produced via lipid peroxidation during oxidative stress. Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) is able to oxidise both medium- and long-chain aldehydes. C16 aldehydes such as hexadecanal (HXAL) generated through sphingolipid metabolism on the plasma membrane can be oxidised to palmitic acid (PALM) (Marchitti et al., 2007; Kitamura et al. 2013). 4HNE, amongst other reactive medium-chain aldehydes, can be detoxified by oxidation to 4-hydroxynonenoic acid (4HNA) by ALDH3B1, suggesting a potential physiological role for ALDH3B1 against oxidative stress (not shown here) (Marchitti et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
17382292	Expression and initial characterization of human ALDH3B1 Orlicky, DJ, Vasiliou, V, Marchitti, SA	Biochem Biophys Res Commun	2007
23721920	Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1 Abe, K, Nakahara, K, Ohno, Y, Kitamura, T, Kihara, A, Naganuma, T	Biochim. Biophys. Acta	2013
20699116	Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress Orlicky, DJ, Brocker, C, Vasiliou, V, Marchitti, SA	Free Radic. Biol. Med.	2010