ALDH3B1 oxidises HXAL to PALM

Stable Identifier
Reaction [transition]
Homo sapiens
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Aldehyde dehydrogenases (ALDHs) detoxify toxic aldehydes by oxidation to the corresponding carboxylic acids. Long-chain aliphatic aldehydes are largely produced by catabolic metabolism of several lipids, including ether glycerolipids, fatty alcohols, sphingolipids and wax esters. Some medium-chain aliphatic aldehydes, such as hexanal, octanal and 4-hydroxy-2-nonenal (4HNE) are produced via lipid peroxidation during oxidative stress. Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) is able to oxidise both medium- and long-chain aldehydes. C16 aldehydes such as hexadecanal (HXAL) generated through sphingolipid metabolism on the plasma membrane can be oxidised to palmitic acid (PALM) (Marchitti et al., 2007; Kitamura et al. 2013). 4HNE, amongst other reactive medium-chain aldehydes, can be detoxified by oxidation to 4-hydroxynonenoic acid (4HNA) by ALDH3B1, suggesting a potential physiological role for ALDH3B1 against oxidative stress (not shown here) (Marchitti et al. 2010).
Literature References
PubMed ID Title Journal Year
17382292 Expression and initial characterization of human ALDH3B1

Orlicky, DJ, Vasiliou, V, Marchitti, SA

Biochem Biophys Res Commun 2007
23721920 Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1

Abe, K, Nakahara, K, Ohno, Y, Kitamura, T, Kihara, A, Naganuma, T

Biochim. Biophys. Acta 2013
20699116 Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress

Orlicky, DJ, Brocker, C, Vasiliou, V, Marchitti, SA

Free Radic. Biol. Med. 2010
Catalyst Activity

aldehyde dehydrogenase [NAD(P)+] activity of ALDH3B1 [plasma membrane]

Orthologous Events
Cross References
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