ACER1 hydrolyzes ceramide (endoplasmic reticulum)

Stable Identifier
Reaction [transition]
Homo sapiens
ceramide + H2O <=> fatty acid + sphingosine (endoplasmic reticulum)
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ACER1 (alkaline ceramidase 1) catalyzes the reversible hydrolysis of ceramide to yield a free fatty acid and sphingosine (Sun et al. 2008). ACER1 hydrolyses C20:0-C24:0 ceramides, localizes to the endoplasmic reticulum membrane, and is mainly expressed in skin tissue (Casasampere et al., 2015). ACER1 is believed to be a key regulator of keratinocyte differentiation and has a fundamental role in skin barrier formation (Liakath-Ali et al., 2016; reviewed by Mao & Obeid, 2008; Parveen et al., 2019; Duarte et al., 2020).
Literature References
PubMed ID Title Journal Year
17713573 Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes

Thiers, BH, Mao, C, Crellin, HA, Sun, W, Hu, W, Jin, J, Bielawski, J, Xu, R, Obeid, LM, Szulc, ZM

J Invest Dermatol 2008
26286360 Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols

Egido-Gabás, M, Casas, J, Canals, D, Camacho, L, Bedia, C, Fabrias, G, Wang, K, Mao, C, Cingolani, F, Casasampere, M, Xu, R, Abad, JL, Hannun, YA

J Lipid Res 2015
31817238 Role of Ceramidases in Sphingolipid Metabolism and Human Diseases

Mishra, VK, Bender, D, Law, SH, Chen, CC, Ke, LY, Parveen, F

Cells 2019
27126290 Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure

Brenn, T, Green, A, Vancollie, VE, Lelliott, CJ, van der Weyden, L, Vizcay-Barrena, G, Arends, MJ, Karp, NA, Glover, L, Spiegel, S, Liakath-Ali, K, Adams, DJ, Gleeson, D, Protheroe, HJ, Watt, FM, Galli, A, Speak, AO, Ryder, E, Lafont, D, Ingvorsen, C

J Pathol 2016
18619555 Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

Mao, C, Obeid, LM

Biochim Biophys Acta 2008
32498325 Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration

Mao, C, Yamada, C, Movila, A, Ho, A, Akkaoui, J, Duarte, C

Cells 2020
Catalyst Activity

N-acylsphingosine amidohydrolase activity of ACER1 [endoplasmic reticulum membrane]

Orthologous Events
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