PLPP1 dephosphorylates extracellular sphingosine-1-phosphate

Stable Identifier
R-HSA-428690
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]
ReviewStatus
5/5
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Phospholipid phosphatase 2 (PLPP2, PPAP2A, LPP3) enzyme associated with the plasma membrane catalyzes the hydrolysis of extracellular sphingosine 1-phosphate (S1P) to form sphingosine and orthophosphate. The reaction is essential for removing S1P from plasma and cell uptake of sphingosine (Roberts et al., 1998; Zhao et al., 2007; reviewed by Tang et al., 2015).
Literature References
PubMed ID Title Journal Year
9705349 Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.

Morris, AJ, Roberts, R, Sciorra, VA

J Biol Chem 1998
25814022 Lipid phosphate phosphatases and their roles in mammalian physiology and pathology

Tang, X, Benesch, MG, Brindley, DN

J Lipid Res 2015
17379599 Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1

Garcia, JG, Gorshkova, I, Watkins, T, Bittman, R, Kalari, SK, Zhao, Y, Natarajan, V, Sun, C, Brindley, DN, He, D, Usatyuk, PV, Berdyshev, EV

J Biol Chem 2007
Participants
Participates
Catalyst Activity

sphingosine-1-phosphate phosphatase activity of PLPP1 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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