Reactome | FFAR2 [plasma membrane]

FFAR2 [plasma membrane]

Stable Identifier

R-HSA-443944

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Free fatty acid receptor 2, FFAR2_HUMAN, GPR43

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15552 FFAR2

Gene Names

FFAR2, FFA2, GPCR43, GPR43

Chain

chain:1-330

Reference Genes

BioGPS Gene:2867 FFAR2

COSMIC (genes):FFAR2 FFAR2

CTD Gene:2867 FFAR2

dbSNP Gene:2867 FFAR2

ENSEMBL:ENSG00000126262 FFAR2

ENSEMBL_homo_sapiens_GENE:ENSG00000126262.5 FFAR2

HGNC:4501 FFAR2

KEGG Gene (Homo sapiens):2867 FFAR2

Monarch:2867 FFAR2

NCBI Gene:2867 FFAR2

OMIM:603823 FFAR2

UCSC:O15552 FFAR2

Reference Transcript

Other Identifiers

11735183_at

16861030

221345_PM_at

221345_at

2867

3830488

3830489

3830490

3830491

3830492

3830493

8027862

A_14_P135890

A_23_P397391

GE62969

GO:0002232

GO:0002376

GO:0002385

GO:0002673

GO:0002720

GO:0002752

GO:0002879

GO:0004930

GO:0005515

GO:0005886

GO:0006954

GO:0007165

GO:0007186

GO:0007200

GO:0008289

GO:0016020

GO:0019915

GO:0023052

GO:0030154

GO:0032024

GO:0032722

GO:0032757

GO:0042593

GO:0042995

GO:0045444

GO:0046676

GO:0048870

GO:0060089

GO:0071398

GO:0090276

GO:0098542

GO:1990806

HMNXSV003005693

ILMN_1797895

TC19000470.hg

g4885332_3p_at

Participates

as an input of

Receptor FFAR2 binds carboxylates (Homo sapiens)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

FFAR2:FFAR2 ligands [plasma membrane] (Homo sapiens)

Inferred To

ffar2 [plasma membrane] (Xenopus tropicalis)

si:dkey-211g8.7 [plasma membrane] (Danio rerio)

FFAR2 [plasma membrane] (Bos taurus)

FFAR2 [plasma membrane] (Canis familiaris)

FFAR2 [plasma membrane] (Gallus gallus)

FFAR2 [plasma membrane] (Sus scrofa)

Ffar2 [plasma membrane] (Mus musculus)

Ffar2 [plasma membrane] (Rattus norvegicus)

Homologues of FFAR2 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_005297.1, XP_016882200.1, XP_016882198.1, XP_016882199.1

Guide to Pharmacology - Targets

226

OpenTargets

ENSG00000126262

ZINC - Substances

FFAR2_HUMAN

ZINC target

O15552

PRO

O15552

PDB

8J22, 8J24

GeneCards

O15552

HPA

ENSG00000126262-FFAR2

Ensembl

ENSG00000126262, ENST00000599180, ENSP00000473159, ENST00000246549, ENSP00000246549

Pharos - Targets

O15552

ZINC - Predictions - Purchasable

FFAR2_HUMAN

HMDB Protein

HMDBP02026

Interactors (110)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H7V2 SYNG1			0.556	3
UniProt:Q9Y6I9 TEX264	2	TEX264 [extracellular region] (R-HSA-8863002) TEX264 [platelet alpha granule lumen] (R-HSA-8863000)	0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:Q92520 FAM3C	2	FAM3C [extracellular region] (R-HSA-8848922) FAM3C [platelet dense granule lumen] (R-HSA-8848884)	0.556	3
UniProt:P04264 KRT1	3	KRT1 [cytosol] (R-HSA-6809649) KRT1 [extracellular region] (R-HSA-6800471) KRT1 [ficolin-1-rich granule lumen] (R-HSA-6800428)	0.556	3
UniProt:Q99675 CGRF1			0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q9NRQ5 SMCO4			0.556	3
UniProt:Q8WVX3-2 C4ORF3			0.556	3
UniProt:B2RUZ4 SMIM1			0.556	3
UniProt:Q5J8X5 M4A13			0.556	3
UniProt:O14735 CDIPT	1	CDIPT [endoplasmic reticulum membrane] (R-HSA-1498749)	0.556	3
IntAct:EBI-22589183 CCSB ORF ID			0.556	3
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
IntAct:EBI-23624354 CCSB ORF ID			0.556	3
UniProt:O75063 XYLK			0.556	3
UniProt:Q6N075 MFSD5			0.556	3
UniProt:Q8NH19 OR10AG1	1	OR10AG1 [endoplasmic reticulum membrane] (R-HSA-9751392)	0.556	3
UniProt:Q9Y3D6 FIS1	2	FIS1 [peroxisomal membrane] (R-HSA-9033123) FIS1 [cytosol] (R-HSA-9033099)	0.556	3
UniProt:Q0VAQ4 SMAGP			0.556	3
UniProt:Q96F05 CK024			0.556	3
UniProt:O95214 LERL1			0.556	3
UniProt:Q9NRZ5 AGPAT4	1	AGPAT4 [endoplasmic reticulum membrane] (R-HSA-61809)	0.556	3
UniProt:P20292 ALOX5AP	1	ALOX5AP [nuclear envelope] (R-HSA-2318768)	0.556	3
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:Q9NUM3 S39A9			0.556	3
UniProt:Q8IXM6 NRM			0.556	3
UniProt:Q02747 GUCA2A	1	GUCA2A(22-115) [extracellular region] (R-HSA-8936191)	0.556	3
UniProt:O95968 SG1D1			0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:Q06432 CCG1			0.556	3
UniProt:Q8IVJ1 SLC41A1	1	SLC41A1 [plasma membrane] (R-HSA-442659)	0.556	3
UniProt:P29400-2 COL4A5			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q5BJF2 SGMR2			0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:Q7Z769 S35E3			0.556	3
UniProt:Q7Z5S9 TM144			0.556	3
UniProt:P48230 T4S4			0.556	3
UniProt:O75841 UPK1B			0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:E9PQX1 TM262			0.556	3
UniProt:Q9UNK0 STX8			0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:P27701 CD82			0.556	3
UniProt:P0DN84 DWORF			0.556	3
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:Q9BVK8 TM147			0.556	3
UniProt:P42857 NSG1			0.556	3
UniProt:Q8N3T1 GALNT15	1	GALNT15 [Golgi membrane] (R-HSA-913705)	0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:Q8NBI2 CYAC3			0.556	3
UniProt:Q9UBY5 LPAR3	1	LPAR3 [plasma membrane] (R-HSA-419379)	0.556	3
UniProt:Q8WW34-2 TMEM239			0.556	3
UniProt:P54315 PNLIPRP1	1	PNLIPRP1 [extracellular region] (R-HSA-3902876)	0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q5TGU0 TSPO2			0.556	3
UniProt:P56851 EP3B			0.556	3
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.556	3
UniProt:Q969S6 TM203			0.556	3
UniProt:Q9UKR5 ERG28			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q96EC8 YIPF6	2	YIPF6 [Golgi membrane] (R-HSA-434346) YIPF6 [cytoplasmic vesicle membrane] (R-HSA-434199)	0.556	3
UniProt:Q15012 LAP4A			0.556	3
UniProt:Q8TAF8 LHFPL5	1	LHFPL5 [plasma membrane] (R-HSA-9658860)	0.556	3
UniProt:O14493 CLDN4	2	CLDN4 [plasma membrane] (R-HSA-419987) CLDN4 [cell junction] (R-HSA-421244)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q86UP2-3 KTN1			0.556	3
UniProt:Q16617 NKG7			0.556	3
UniProt:Q9UHE5 NAT8	1	NAT8 [endoplasmic reticulum membrane] (R-HSA-5692986)	0.556	3
UniProt:P02724 GYPA	1	GYPA [plasma membrane] (R-HSA-8867204)	0.556	3
UniProt:A0PK00 T120B			0.556	3
UniProt:Q9P0B6 CC167			0.556	3
UniProt:Q8NC01 CLC1A			0.556	3
UniProt:Q9HD20-3 ATP13A1			0.556	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:Q8NHS1 CLDN2			0.556	3
UniProt:Q9BXR6 CFHR5	1	CFHR5 [extracellular region] (R-HSA-8851419)	0.556	3
UniProt:Q53HI1 UNC50			0.556	3
UniProt:Q9NQQ7-3 Q9NQQ73			0.556	3
UniProt:Q12983 BNIP3			0.556	3
UniProt:Q0D2K0 NIPAL4	1	NIPAL4 [plasma membrane] (R-HSA-5216046)	0.556	3
UniProt:CXCL16 A0A6I8PIU0			0.556	3
UniProt:Q9Y6D0 SELK			0.556	3
UniProt:Q07325 CXCL9	1	CXCL9 [extracellular region] (R-HSA-373856)	0.556	3
UniProt:Q9BWQ6 YIPF2			0.556	3
UniProt:P27352 CBLIF	3	CBLIF S27Cfs*23 [extracellular region] (R-HSA-3315461) CBLIF [extracellular region] (R-HSA-2980918) CBLIF [lysosomal lumen] (R-HSA-3000272)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.556	3
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.556	3
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:O95406 CNIH1	3	CNIH1 [endoplasmic reticulum membrane] (R-HSA-5689439) CNIH1 [ER to Golgi transport vesicle membrane] (R-HSA-5689776) CNIH1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689778)	0.556	3
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.556	3
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:O00602-PRO_0000009136 FCN1			0.505	7
UniProt:P0DTD8 NS7B			0.488	2
UniProt:P0DTD3 ORF9C			0.488	2
UniProt:P02741 CRP	1	CRP(19-224) [extracellular region] (R-HSA-976719)	0.454	2

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