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ZNF649 [nucleoplasm]
Stable Identifier
R-HSA-2127585
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Zinc finger protein 649, ZN649_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by KRAB-ZFP proteins (Homo sapiens)
ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)
CBX5:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
KRAB-ZFP binds retroelement DNA in chromatin (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement (Homo sapiens)
NuRD:SUMO2-6K-TRIM28:KRAB-ZNF:retroelement chromatin [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
TRIM28 (KAP1) binds KRAB-ZFP in KRAB-ZFP:retroelement chromatin (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2 (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
KRAB-ZNF / KAP Interaction (Homo sapiens)
KRAB-ZNF / KAP Complex [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
ZNF649 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BS31 ZNF649
Gene Names
ZNF649
Chain
chain:1-505
Reference Genes
BioGPS Gene:65251 ZNF649
COSMIC (genes):ZNF649 ZNF649
CTD Gene:65251 ZNF649
dbSNP Gene:65251 ZNF649
ENSEMBL:ENSG00000198093 ZNF649
HGNC:25741 ZNF649
KEGG:hsa:65251 ZNF649
Monarch:65251 ZNF649
NCBI Gene:65251 ZNF649
OMIM:611903 ZNF649
UCSC:Q9BS31 ZNF649
Reference Transcript
RefSeq:NM_023074.3 ZNF649
Other Identifiers
11731507_at
11731508_a_at
16874970
223616_PM_at
223616_at
3869309
3869310
3869311
3869313
3869314
3869315
3869316
3869317
3869318
3869319
3869320
3869321
3869322
3869323
3869372
65251
8038913
89209_r_at
A_23_P208208
A_24_P233256
GE85617
GO:0000978
GO:0003677
GO:0003700
GO:0005515
GO:0005615
GO:0005634
GO:0006355
GO:0006357
GO:0008270
GO:0043226
GO:0140110
HMNXSV003030368
ILMN_1699249
PH_hs_0009498
PH_hs_0021499
TC19001789.hg
g13529205_3p_at
Participates
as a candidate of
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
Inferred To
klu [nucleoplasm]
(Drosophila melanogaster)
si:ch73-266f23.4 [nucleoplasm]
(Danio rerio)
ztf-2 [nucleoplasm]
(Caenorhabditis elegans)
Dmel\CG9215 [nucleoplasm]
(Drosophila melanogaster)
ZNF649 [nucleoplasm]
(Caenorhabditis elegans)
ZNF649 [nucleoplasm]
(Danio rerio)
ZNF649 [nucleoplasm]
(Gallus gallus)
klu-2 [nucleoplasm]
(Caenorhabditis elegans)
klu-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of ZNF649 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of ZNF649 [nucleoplasm]
(Danio rerio)
Homologues of ZNF649 [nucleoplasm]
(Drosophila melanogaster)
Dmel\CG7963 [nucleoplasm]
(Drosophila melanogaster)
tra-4 [nucleoplasm]
(Caenorhabditis elegans)
Zaf1 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_075562.2
ENSEMBL
ENSG00000198093
,
ENST00000354957
,
ENSP00000347043
OpenTargets
ENSG00000198093
GeneCards
ZNF649
HPA
ENSG00000198093-ZNF649
PRO
Q9BS31
Pharos - Targets
Q9BS31
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13263 TRIM28
3
TRIM28 [nucleoplasm]
(R-HSA-974998)
SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm]
(R-HSA-9842867)
SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]
(R-HSA-3782600)
0.669
3
UniProt:P02545 LMNA
3
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
0.556
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
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