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AREG [extracellular region]
Stable Identifier
R-HSA-9624190
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
AREG(101-187), fullName evidence="8"Amphiregulin, AREG_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9Y5W9 SNX11
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Developmental Cell Lineages of the Integumentary System (Homo sapiens)
Developmental Lineages of the Mammary Gland (Homo sapiens)
Developmental Lineage of Mammary Gland Luminal Epithelial Cells (Homo sapiens)
Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell (Homo sapiens)
AREG [extracellular region] (Homo sapiens)
Mammary stem cell produces hormone receptor negative luminal progenitor cell (Homo sapiens)
AREG [extracellular region] (Homo sapiens)
Mammary stem cell produces hormone receptor positive luminal progenitor cell (Homo sapiens)
AREG [extracellular region] (Homo sapiens)
Developmental Lineage of Mammary Gland Myoepithelial Cells (Homo sapiens)
Mammary stem cell produces myoepithelial/basal progenitor (Homo sapiens)
AREG [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15514 AREG
Gene Names
AREG, AREGB, SDGF
Chain
signal peptide:1-19, propeptide:20-100, chain:101-187, propeptide:188-252
Reference Genes
BioGPS Gene:374 AREG
COSMIC - genes:AREG AREG
CTD Gene:374 AREG
dbSNP Gene:374 AREG
ENSEMBL:ENSG00000109321 AREG
HGNC:651 AREG
KEGG:hsa:374 AREG
Monarch:374 AREG
NCBI Gene:374 AREG
OMIM:104640 AREG
UCSC:P15514 AREG
Reference Transcript
RefSeq:NM_001657.4 AREG
Other Identifiers
11715306_s_at
16967853
16967863
205239_PM_at
205239_at
2731541
2731543
2731544
2731545
2731546
2731547
2731548
2731551
2731552
2731553
2731554
2731555
2731556
2731558
2731559
2731561
34898_at
374
8095736
8095744
A_14_P115708
A_23_P259071
A_33_P3419190
GE62938
GO:0005125
GO:0005154
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005789
GO:0007173
GO:0007186
GO:0007267
GO:0008083
GO:0008284
GO:0009986
GO:0010838
GO:0012507
GO:0014009
GO:0016020
GO:0030297
GO:0030669
GO:0031175
GO:0032355
GO:0033116
GO:0038134
GO:0042327
GO:0042542
GO:0043434
GO:0045668
GO:0048018
GO:0048856
GO:0051384
GO:0051591
GO:0060598
GO:0060744
GO:0060749
GO:0060750
GO:0098772
HMNXSV003029092
M30703_s_at
PH_hs_0013934
PH_hs_0035731
TC04002952.hg
TC04002953.hg
g4502198_3p_at
Participates
as a member of
EGF-like ligands [extracellular region] (Homo sapiens)
This entity regulates
Negatively
Mammary stem cell produces myoepithelial/basal progenitor
(Homo sapiens)
Positively
Mammary stem cell produces hormone receptor positive luminal progenitor cell
(Homo sapiens)
Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell
(Homo sapiens)
Mammary stem cell produces hormone receptor negative luminal progenitor cell
(Homo sapiens)
Other forms of this molecule
AREG(101-187) [clathrin-coated endocytic vesicle membrane]
AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
AREG precursor [ER to Golgi transport vesicle membrane]
AREG precursor [endoplasmic reticulum membrane]
Inferred To
areg [extracellular region]
(Xenopus tropicalis)
hbegfa [extracellular region]
(Danio rerio)
Areg [extracellular region]
(Mus musculus)
Areg [extracellular region]
(Rattus norvegicus)
AREG [extracellular region]
(Bos taurus)
AREG [extracellular region]
(Canis familiaris)
AREG [extracellular region]
(Gallus gallus)
AREG [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001648.1
ENSEMBL
ENST00000395748
,
ENSP00000379097
,
ENSG00000109321
OpenTargets
ENSG00000109321
GeneCards
AREG
HPA
ENSG00000109321-AREG
ZINC - Substances
AREG_HUMAN
ZINC target
P15514
PRO
P15514
Pharos - Targets
P15514
GlyGen
P15514
ZINC - Predictions - Purchasable
AREG_HUMAN
PDB
2RNL
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26447 S10A4
0.683
5
IntAct:EBI-10171679 386682
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:O60503 ADCY9
1
ADCY9 [plasma membrane]
(R-HSA-379055)
0.527
2
UniProt:P05362 ICAM1
1
ICAM1 [plasma membrane]
(R-HSA-197683)
0.527
2
UniProt:Q9Y5W9 SNX11
0.527
2
UniProt:P06921 VE2
0.488
2
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