Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
hbegfa [extracellular region]
Stable Identifier
R-DRE-9624190
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
extracellular region
Synonyms
AREG, A9JRW9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
EGFR autophosphorylation (Danio rerio)
EGF-like ligands:EGFR dimer [plasma membrane] (Danio rerio)
EGFR:EGF-like ligands [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGFR binds EGF ligand (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGFR:EGF-like ligands [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGFR dimerization (Danio rerio)
EGF-like ligands:EGFR dimer [plasma membrane] (Danio rerio)
EGFR:EGF-like ligands [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGFR:EGF-like ligands [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGFR downregulation (Danio rerio)
Binding of CBL to EGFR (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
CBL ubiquitinates Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Localization of CBL:GRB2 to the membrane (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Phosphorylation of CBL (EGFR:CBL) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Ubiquitination of stimulated EGFR (CBL) (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGFR interacts with phospholipase C-gamma (Danio rerio)
Active PLC-gamma1 dissociates from EGFR (Danio rerio)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGFR activates PLC-gamma1 by phosphorylation (Danio rerio)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Phospholipase C-gamma1 binds to the activated EGF receptor (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
GAB1 signalosome (Danio rerio)
GAB1 phosphorylation by EGFR kinase (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
GRB2 events in EGFR signaling (Danio rerio)
GRB2:SOS1 complex binds to EGF:EGFR complex (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
Phosphorylation of EGFR by SRC kinase (Danio rerio)
EGF-like ligands:EGFR dimer [plasma membrane] (Danio rerio)
EGFR:EGF-like ligands [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
SHC1 events in EGFR signaling (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Danio rerio)
EGF-like ligands [extracellular region] (Danio rerio)
hbegfa [extracellular region] (Danio rerio)
External Reference Information
External Reference
UniProt:A9JRW9
Gene Names
hbegfa
Reference Genes
BioGPS Gene:797938 hbegfa
CTD Gene:797938 hbegfa
ENSEMBL:ENSDARG00000075121
KEGG:dre:797938 hbegfa
Monarch:797938 hbegfa
NCBI Gene:797938 hbegfa
UCSC:A9JRW9 hbegfa
Reference Transcript
RefSeq:NM_001111226.1 hbegfa
Other Identifiers
13007900
797938
A_15_P117411
A_15_P405805
A_15_P415285
A_15_P486475
A_15_P734371
CJ007041
CJ007042
CUST_1244_PI428451958
DRER17837
DRER47144
Dr.16053.1.S1_at
ENSDART00000109138
GT_Spec_NM_001111226.1_198315
JP007439
JP007440
ZV700S00001990
Participates
as a member of
EGF-like ligands [extracellular region] (Danio rerio)
Other forms of this molecule
hbegfa [plasma membrane]
hbegfa [ER to Golgi transport vesicle membrane]
hbegfa [endoplasmic reticulum membrane]
hbegfa [plasma membrane]
hbegfa [extracellular region]
Inferred From
AREG [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001104696.1
ENSEMBL
ENSDARG00000075121
,
ENSDARP00000099541
,
ENSDART00000109138
ZFIN
ZDB-GENE-080204-119
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
