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AREG precursor [ER to Golgi transport vesicle membrane]
Stable Identifier
R-HSA-5689771
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ER to Golgi transport vesicle membrane
Synonyms
SDGF, AREGB, Amphiregulin, AREG (20-252)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15514 AREG
Gene Names
AREG, AREGB, SDGF
Chain
signal peptide:1-19, propeptide:20-100, chain:101-187, propeptide:188-252
Reference Genes
BioGPS Gene:374 AREG
COSMIC (genes):AREG AREG
CTD Gene:374 AREG
dbSNP Gene:374 AREG
ENSEMBL:ENSG00000109321 AREG
ENSEMBL_homo_sapiens_GENE:ENSG00000109321.11 AREG
HGNC:651 AREG
KEGG Gene (Homo sapiens):374 AREG
Monarch:374 AREG
NCBI Gene:374 AREG
OMIM:104640 AREG
UCSC:P15514 AREG
Reference Transcript
RefSeq:NM_001657.3 AREG
Other Identifiers
11715306_s_at
16967853
16967863
205239_PM_at
205239_at
2731541
2731543
2731544
2731545
2731546
2731547
2731548
2731552
2731553
2731554
2731555
2731556
2731558
2731561
34898_at
374
8095736
8095744
A_14_P115708
A_23_P259071
A_33_P3419190
GE62938
GO:0005125
GO:0005154
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005783
GO:0005789
GO:0007173
GO:0007186
GO:0007267
GO:0008083
GO:0008284
GO:0009986
GO:0010838
GO:0012507
GO:0014009
GO:0014070
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0030297
GO:0030669
GO:0031175
GO:0031410
GO:0032355
GO:0033116
GO:0036211
GO:0038134
GO:0042327
GO:0042542
GO:0043226
GO:0043434
GO:0045668
GO:0048018
GO:0048856
GO:0050731
GO:0051384
GO:0051591
GO:0060598
GO:0060744
GO:0060749
GO:0060750
GO:0098772
HMNXSV003029092
M30703_s_at
PH_hs_0013934
PH_hs_0035731
TC04002952.hg
TC04002953.hg
g4502198_3p_at
Participates
as a member of
TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Homo sapiens)
Other forms of this molecule
AREG(101-187) [clathrin-coated endocytic vesicle membrane]
AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
AREG precursor [endoplasmic reticulum membrane]
AREG(101-187) [extracellular region]
Inferred To
areg [ER to Golgi transport vesicle membrane]
(Xenopus tropicalis)
AREG [ER to Golgi transport vesicle membrane]
(Bos taurus)
AREG [ER to Golgi transport vesicle membrane]
(Canis familiaris)
AREG [ER to Golgi transport vesicle membrane]
(Gallus gallus)
AREG [ER to Golgi transport vesicle membrane]
(Sus scrofa)
Areg [ER to Golgi transport vesicle membrane]
(Mus musculus)
Areg [ER to Golgi transport vesicle membrane]
(Rattus norvegicus)
AREG precursor [ER to Golgi transport vesicle membrane]
(Danio rerio)
Cross References
RefSeq
NP_001648.1
OpenTargets
ENSG00000109321
ZINC - Substances
AREG_HUMAN
HPA
ENSG00000109321-AREG
GeneCards
P15514
Ensembl
ENST00000395748
,
ENSG00000109321
,
ENSP00000379097
ZINC target
P15514
PRO
P15514
Pharos - Targets
P15514
ZINC - Predictions - Purchasable
AREG_HUMAN
PDB
2RNL
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26447 S10A4
0.683
5
IntAct:EBI-10171679 386682
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P06921 VE2
0.488
2
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