Reactome | Areg [extracellular region]

Areg [extracellular region]

Stable Identifier

R-RNO-9624190

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

AREG, P24338

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands [extracellular region] (Rattus norvegicus)
        
        Areg [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P24338

Gene Names

Areg

Reference Genes

BioGPS Gene:29183 Areg

ENSEMBL:ENSRNOG00000002754

ENSEMBL:ENSRNOG00055006387

ENSEMBL:ENSRNOG00060017437

ENSEMBL:ENSRNOG00065018693

KEGG:rno:29183 Areg

Monarch:29183 Areg

NCBI Gene:29183 Areg

UCSC:P24338 Areg

Reference Transcript

RefSeq:NM_017123.2 Areg

Other Identifiers

10775866

1369871_at

17693425

29183

6047246

6259282

6322352

6408633

6425245

6487267

6530692

6546529

A_42_P791677

GE20356

GO:0005615

GO:0005634

GO:0005737

GO:0007173

GO:0007186

GO:0008284

GO:0009986

GO:0030297

GO:0032355

GO:0038134

GO:0048018

GO:0048856

GO:0060598

GO:0060744

GO:0060749

GO:0060750

GO:0098772

ILMN_1363074

PH_rn_0015046

X55183_at

Participates

as a member of

EGF-like ligands [extracellular region] (Rattus norvegicus)

Other forms of this molecule

Areg [clathrin-coated endocytic vesicle membrane]

Areg [endoplasmic reticulum-Golgi intermediate compartment membrane]

Areg [ER to Golgi transport vesicle membrane]

Areg [endoplasmic reticulum membrane]

Inferred From

AREG [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_058819.1

ENSEMBL

ENSRNOP00000003703, ENSRNOG00000002754, ENSRNOT00000003703

PRO

P24338

GlyGen

P24338

RGD

2149

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