Reactome | AREG [extracellular region]

AREG [extracellular region]

Stable Identifier

R-GGA-9624190

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

extracellular region

Synonyms

AREG, Q645M5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
        
        EGF-like ligands [extracellular region] (Gallus gallus)
        
        AREG [extracellular region] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q645M5

Gene Names

AREG

Reference Genes

BioGPS Gene:428752 AREG

ENSEMBL:ENSGALG00010003223.1

KEGG:gga:428752 AREG

Monarch:428752 AREG

NCBI Gene:428752 AREG

UCSC:Q645M5 AREG

Reference Transcript

RefSeq:NM_001031537.2 AREG

Other Identifiers

428752

GO:0005154

GO:0005615

GO:0005634

GO:0005737

GO:0007173

GO:0007186

GO:0008083

GO:0008284

GO:0009986

GO:0016020

GO:0030297

GO:0032355

GO:0038134

GO:0048018

GO:0098772

GT_A_87_P035067

GT_Sp_ENSGALT00000017665_1571

GT_Sp_ENSGALT00000017665_1572

GT_Sp_ENSGALT00000017665_1580

GgaAffx.6867.1.S1_at

Participates

as a member of

EGF-like ligands [extracellular region] (Gallus gallus)

Other forms of this molecule

AREG [clathrin-coated endocytic vesicle membrane]

AREG [ER to Golgi transport vesicle membrane]

AREG [endoplasmic reticulum membrane]

Inferred From

AREG [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001026708.1

ENSEMBL

ENSGALG00010003223, ENSGALT00010007542, ENSGALP00010004497

PRO

Q645M5

Cite Us!