Reactome | ADCY9 [plasma membrane]

ADCY9 [plasma membrane]

Stable Identifier

R-HSA-379055

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase type 9, ADCY9_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of adenylate cyclase pathway (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY9 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60503 ADCY9

Gene Names

ADCY9, KIAA0520

Chain

chain:1-1353

Reference Genes

BioGPS Gene:115 ADCY9

COSMIC (genes):ADCY9 ADCY9

CTD Gene:115 ADCY9

dbSNP Gene:115 ADCY9

ENSEMBL:ENSG00000162104 ADCY9

ENSEMBL_homo_sapiens_GENE:ENSG00000162104 ADCY9

HGNC:240 ADCY9

KEGG Gene (Homo sapiens):115 ADCY9

Monarch:115 ADCY9

NCBI Gene:115 ADCY9

OMIM:603302 ADCY9

UCSC:O60503 ADCY9

Reference Transcript

RefSeq:NM_001116.3 ADCY9

Other Identifiers

115

11721065_at

11721066_at

11758076_s_at

16823477

204497_at

204498_s_at

33800_at

3677915

3677916

3677917

3677918

3677919

3677921

3677923

3677924

3677928

3677930

3677931

3677935

3677938

3677954

3677955

3677956

3677957

41328

44225

7999079

A_23_P49443

A_24_P935103

AAC24201

AAI36658

AAI36659

AAI51208

AAI51230

AAK29464

AAY21237

AAY27880

AB011092

ADCY9

ADCY9-201

AF036927

AJ133123

AY028949

AY028950

AY028951

AY028952

AY028953

AY028954

AY028955

AY028956

AY028957

AY028959

BAA25446

BC136657

BC136658

BC151207

BC151229

CAB65084

CCDS32382

CH471112

DQ005545

DQ008441

EAW85331

EAW85332

ENSG00000162104

ENSP00000294016

ENST00000294016

EntrezGene:115

g4557258_3p_a_at

GO:0000166

GO:0003091

GO:0003674

GO:0004016

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005886

GO:0005887

GO:0006171

GO:0007165

GO:0007186

GO:0007189

GO:0007193

GO:0008150

GO:0009058

GO:0009190

GO:0016020

GO:0016021

GO:0016829

GO:0016849

GO:0030424

GO:0030425

GO:0034641

GO:0035556

GO:0042592

GO:0043167

GO:0044281

GO:0046872

GO:0071377

GO:0071880

HGNC:240

HPA041328

HPA044225

Hs.20196.0.S2_3p_at

I3NI20

ILMN_1654287

IPR001054

IPR018297

IPR029787

MIM:603302

NM_001116

NP_001107

PF00211

PH_hs_0031049

SM00044

TC16000824.hg

uc002cvx.4

UPI000012887F

XM_005255079

XM_011522353

XP_005255136

XP_011520655

Participant Of

hasCandidate

adenylate cyclases [plasma membrane]

hasMember

Adenylate cyclase [plasma membrane]

Inferred To

Homologues of ADCY9 [plasma membrane] (Canis familiaris)

Homologues of ADCY9 [plasma membrane] (Danio rerio)

Homologues of ADCY9 [plasma membrane] (Drosophila melanogaster)

Homologues of ADCY9 [plasma membrane] (Gallus gallus)

Homologues of ADCY9 [plasma membrane] (Sus scrofa)

Homologues of ADCY9 [plasma membrane] (Taeniopygia guttata)

ADCY9 [plasma membrane] (Bos taurus)

ADCY9 [plasma membrane] (Caenorhabditis elegans)

ADCY9 [plasma membrane] (Canis familiaris)

ADCY9 [plasma membrane] (Danio rerio)

ADCY9 [plasma membrane] (Dictyostelium discoideum)

ADCY9 [plasma membrane] (Drosophila melanogaster)

ADCY9 [plasma membrane] (Gallus gallus)

ADCY9 [plasma membrane] (Mus musculus)

ADCY9 [plasma membrane] (Rattus norvegicus)

ADCY9 [plasma membrane] (Sus scrofa)

ADCY9 [plasma membrane] (Taeniopygia guttata)

ADCY9 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001107.2

OpenTargets

ENSG00000162104

GeneCards

O60503

PRO

O60503

BRENDA (Homo sapiens)

4.6.1.1

HMDB Protein

HMDBP00709