Reactome | AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]

AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-5689774

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

SDGF, AREGB, Amphiregulin, AREG (20-252)

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        CNIH1:TFGA,AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TFGA, AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        CNIH1:TFGA,AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TFGA, AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15514 AREG

Gene Names

AREG, AREGB, SDGF

Chain

signal peptide:1-19, propeptide:20-100, chain:101-187, propeptide:188-252

Reference Genes

BioGPS Gene:374 AREG

COSMIC (genes):AREG AREG

CTD Gene:374 AREG

dbSNP Gene:374 AREG

ENSEMBL:ENSG00000109321 AREG

HGNC:651 AREG

KEGG Gene (Homo sapiens):374 AREG

Monarch:374 AREG

NCBI Gene:374 AREG

OMIM:104640 AREG

UCSC:P15514 AREG

Reference Transcript

RefSeq:NM_001657.3 AREG

Other Identifiers

0002570372

11715306_s_at

16967853

16967863

205239_at

2731541

2731543

2731544

2731545

2731546

2731547

2731548

2731552

2731553

2731554

2731555

2731556

2731558

2731561

34898_at

374

8095736

8095744

A_14_P115708

A_23_P259071

A_33_P3419190

GE62938

GO:0000003

GO:0000165

GO:0003674

GO:0005125

GO:0005154

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005789

GO:0006464

GO:0006810

GO:0006888

GO:0006950

GO:0007165

GO:0007173

GO:0007186

GO:0007267

GO:0008083

GO:0008150

GO:0008283

GO:0008284

GO:0009986

GO:0010838

GO:0012507

GO:0014009

GO:0014070

GO:0016020

GO:0016021

GO:0016192

GO:0022607

GO:0030154

GO:0030669

GO:0031175

GO:0031410

GO:0032355

GO:0033116

GO:0040007

GO:0042059

GO:0042327

GO:0042542

GO:0043226

GO:0043434

GO:0045668

GO:0045741

GO:0048208

GO:0048856

GO:0050731

GO:0051384

GO:0051591

GO:0051897

GO:0060598

GO:0060744

GO:0060749

GO:0060750

GO:0061024

GO:0065003

HMNXSV003029092

ILMN_3236613

M30703_s_at

PH_hs_0013934

PH_hs_0035731

TC04002952.hg

TC04002953.hg

g4502198_3p_at

Participates

as a member of

TFGA, AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Other forms of this molecule

AREG(101-187) [clathrin-coated endocytic vesicle membrane]

AREG precursor [ER to Golgi transport vesicle membrane]

AREG precursor [endoplasmic reticulum membrane]

AREG(101-187) [extracellular region]

Inferred To

AREG [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)

AREG [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)

AREG [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

Areg [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)

Areg [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)

areg [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)

Cross References

RefSeq

NP_001648.1

OpenTargets

ENSG00000109321

ZINC - Substances

AREG_HUMAN

GeneCards

P15514

HPA

ENSG00000109321-AREG

Ensembl

ENSP00000379097, ENSG00000109321, ENST00000395748

ZINC target

P15514

PRO

P15514

Pharos - Targets

P15514

ZINC - Predictions - Purchasable

AREG_HUMAN

GlyGen

P15514

PDB

2RNL