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Ub-27-UBA52(1-76) [cytosol]
Stable Identifier
R-HSA-5689174
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
SIAH1, SIAH2 ubiquitinate SNCAIP (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Josephin domain DUBs (Homo sapiens)
ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
PARK2 autoubiquitinates (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP10 deubiquitinates SNX3, CFTR (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP11 deubiquitinates NFKBIA (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP25 deubiquitinates DDX58 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
USP5 cleaves polyubiquitin (Homo sapiens)
USP5:PolyUb [cytosol] (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
USP17L2 deubiquitinates RCE1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K27polyUb [cytosol] (Homo sapiens)
K27-Ub [cytosol] (Homo sapiens)
Ub-27-UBA52(1-76) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62987 UBA52
Gene Names
UBA52, UBCEP2
Chain
chain:1-76, chain:77-128
Reference Genes
BioGPS Gene:7311 UBA52
COSMIC (genes):UBA52 UBA52
CTD Gene:7311 UBA52
dbSNP Gene:7311 UBA52
ENSEMBL:ENSG00000221983 UBA52
ENSEMBL_homo_sapiens_GENE:ENSG00000221983.8 UBA52
HGNC:12458 UBA52
KEGG Gene (Homo sapiens):7311 UBA52
Monarch:7311 UBA52
NCBI Gene:7311 UBA52
OMIM:191321 UBA52
Reference Transcript
RefSeq:NM_001321018.1 UBA52
RefSeq:NM_003333.4 UBA52
RefSeq:NM_001321017.1 UBA52
RefSeq:NM_001321020.1 UBA52
RefSeq:NM_001033930.2 UBA52
RefSeq:NM_001321019.1 UBA52
Other Identifiers
11729104_x_at
11756215_x_at
16859825
221700_PM_s_at
221700_s_at
3476750
3537801
3825202
3825203
3825204
3825206
3825207
3825208
3825209
3825210
3825212
3825214
3825216
3825217
3825218
3825219
3825220
3825221
3825222
3825224
58604_s_at
7311
8027024
A_23_P56188
A_23_P56195
A_24_P173325
A_24_P65779
GE79164
GE85590
GE85604
GO:0002181
GO:0003735
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005829
GO:0005840
GO:0005886
GO:0006412
GO:0010008
GO:0015934
GO:0016567
GO:0019941
GO:0022625
GO:0022626
GO:0022627
GO:0030163
GO:0030666
GO:0031386
GO:0031410
GO:0031625
GO:0031982
GO:0036211
GO:0043226
GO:0070062
GO:1990904
HMNXSV003054363
ILMN_1782977
ILMN_2368576
PH_hs_0028727
PH_hs_0037046
TC19000360.hg
X56997_rna1_at
g13569611_3p_s_at
Participates
as a member of
K27-Ub [cytosol] (Homo sapiens)
Other forms of this molecule
UBA52(1-76) [endocytic vesicle membrane]
Ub-33-UBA52(1-76) [mitochondrial outer membrane]
Ub-63-UBA52(1-76) [mitochondrial outer membrane]
Ub-6-UBA52(1-76) [mitochondrial outer membrane]
Ub-11-UBA52(1-76) [mitochondrial outer membrane]
Ub-48-UBA52(1-76) [mitochondrial outer membrane]
Ub-29-UBA52(1-76) [mitochondrial outer membrane]
Ub-27-UBA52(1-76) [mitochondrial outer membrane]
N6-glycyl-L-lysine-UBA52(1-76) [cytosol]
adenylatedG76-UBA52(1-76) [nucleoplasm]
UBA52(1-128) [cytosol]
adenylatedG76-UBA52(1-76) [cytosol]
Ub-48-UBA52(1-76) [endoplasmic reticulum membrane]
Ub-48-UBA52(1-76) [lysosomal membrane]
Ub-48-UBA52(1-76) [endocytic vesicle membrane]
UBA52(1-76) [endosome membrane]
UBA52(1-76) [plasma membrane]
RPL40 [cytosol]
Ub-29-UBA52(1-76) [cytosol]
Ub-6-UBA52(1-76) [cytosol]
Ub-33-UBA52(1-76) [cytosol]
M1-UBA52(1-76) [cytosol]
UBA52(1-76) [endoplasmic reticulum membrane]
Ub-27-UBA52(1-76) [nucleoplasm]
Ub-29-UBA52(1-76) [nucleoplasm]
Ub-33-UBA52(1-76) [nucleoplasm]
Ub-11-UBA52(1-76) [nucleoplasm]
Ub-63-UBA52(1-76) [endosome membrane]
Ub-63-UBA52(1-76) [plasma membrane]
Ub-11-UBA52(1-76) [cytosol]
UBA52(1-76) [nucleoplasm]
Ub-48-UBA52(1-76) [nucleoplasm]
Ub-63-UBA52(1-76) [nucleoplasm]
Ub-6-UBA52(1-76) [nucleoplasm]
UBA52(1-76) [late endosome lumen]
UBA52(1-76) [mitochondrial outer membrane]
Ub-48-UBA52(1-76) [cytosol]
p-S65-UBA52(1-76) [mitochondrial outer membrane]
UBA52(1-76) [cytosol]
UBA52(1-76) [lysosomal lumen]
Ub-63-UBA52(1-76) [cytosol]
Inferred To
UBA52 [cytosol]
(Bos taurus)
UBA52 [cytosol]
(Canis familiaris)
UBA52 [cytosol]
(Sus scrofa)
ubi4 [cytosol]
(Schizosaccharomyces pombe)
Ub-27-RPS27A(1-76) [cytosol]
(Plasmodium falciparum)
UBI4 [cytosol]
(Saccharomyces cerevisiae)
ubqB [cytosol]
(Dictyostelium discoideum)
uba52 [cytosol]
(Danio rerio)
uba52 [cytosol]
(Xenopus tropicalis)
Ubi-p5E [cytosol]
(Drosophila melanogaster)
Ubbl1 [cytosol]
(Rattus norvegicus)
UBB [cytosol]
(Gallus gallus)
ubl-1 [cytosol]
(Caenorhabditis elegans)
Uba52 [cytosol]
(Mus musculus)
Modified Residues
Name
ubiquitinylated lysine at 27
Coordinate
27
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_003324.1
,
NP_001307946.1
,
NP_001307948.1
,
NP_001307947.1
,
NP_001029102.1
,
NP_001307949.1
OpenTargets
ENSG00000221983
GeneCards
P62987
HPA
ENSG00000221983-UBA52
Ensembl
ENST00000595683
,
ENSP00000388107
,
ENSG00000221983
,
ENSP00000471062
,
ENST00000598780
,
ENSP00000471464
,
ENSP00000472264
,
ENST00000599595
,
ENSP00000473048
,
ENST00000595158
,
ENST00000430157
,
ENSP00000470507
,
ENST00000597451
,
ENSP00000470419
,
ENSP00000471622
,
ENSP00000472545
,
ENST00000596273
,
ENST00000596304
,
ENST00000599551
,
ENSP00000396910
,
ENST00000442744
PRO
P62987
Pharos - Targets
P62987
PDB
6QZP
,
4RF1
,
6Y0G
,
5GO7
,
2MBH
,
8OJ8
,
8JDJ
,
5GOG
,
4RF0
,
4UG0
,
4P4H
,
6OLI
,
7ZH3
,
5T2C
,
4JIO
,
8JDK
,
4XKL
,
5GOH
,
5LKS
,
8OHD
,
5GOB
,
7F5S
,
6OLE
,
4V6X
,
5JBV
,
6ZM7
,
5GOC
,
5GOI
,
6XA1
,
6OM0
,
6OLZ
,
6Y57
,
6OLF
,
5JBY
,
6Z6L
,
5AJ0
,
7UN3
,
7AY1
,
6OLG
,
2N3W
,
6Y6X
,
6ZME
,
5HPL
,
5GOK
,
2N3V
,
7M3Q
,
2MJB
,
6OM7
,
4HJK
,
8JDL
,
2MUR
,
8Y0W
,
7OWC
,
6IP5
,
4S1Z
,
6ZMI
,
6Y2L
,
8IFD
,
7ZF1
,
5HPS
,
5J8P
,
4PIJ
,
6Z6M
,
7XNX
,
7XD0
,
7BHP
,
7ZH4
,
8Y0X
,
8JDM
,
6IP6
,
7WFC
,
2NBE
,
8IPJ
,
2N3U
,
7XNY
,
2RSU
,
6ZMO
,
6Z6N
,
4PIH
,
5HPT
,
8QFD
,
8OJ0
,
8IFE
,
6LQM
,
2LJ5
,
6IP8
,
2NBD
,
8OJ5
,
5HPK
,
5GOJ
,
4PIG
,
5GO8
,
5GOD
,
5J26
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y3C5 RNF11
0.666
4
UniProt:Q15038 DAZP2
0.666
7
UniProt:Q9C0C9 UBE2O
1
UBE2O [cytosol]
(R-HSA-947641)
0.659
3
UniProt:Q6ICB0 DESI1
0.601
4
UniProt:Q99732 LITAF
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q9NRQ2 PLS4
0.556
3
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q96CS7 PKHB2
0.556
3
UniProt:Q96B67 ARRD3
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:O95208-2 EPN2
0.556
3
UniProt:Q9UJ41-4 RABGEF1
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:Q92567-2 FAM168A
0.556
3
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q02742 GCNT1
1
GCNT1 [Golgi membrane]
(R-HSA-914020)
0.527
2
UniProt:P49770 EIF2B2
1
EIF2B2 [cytosol]
(R-HSA-72519)
0.527
2
UniProt:Q8WWF5 ZNRF4
0.527
2
UniProt:O43173 ST8SIA3
1
ST8SIA3 [Golgi membrane]
(R-HSA-1022124)
0.527
2
UniProt:Q86UY6 NAA40
0.527
2
UniProt:Q9UBP4 DKK3
0.527
2
UniProt:O15496 PLA2G10
1
PLA2G10 [extracellular region]
(R-HSA-1498793)
0.527
2
UniProt:A4D1S0 KLRG2
0.527
2
UniProt:Q7Z6Z6 PNPLA5
1
PNPLA5 [cytosol]
(R-HSA-8848346)
0.527
2
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.495
2
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