Reactome | Biosynthesis of DHA-derived SPMs

Biosynthesis of DHA-derived SPMs

Stable Identifier

R-HSA-9018677

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Docosahexaenoic acid (DHA), a major ω-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of D-series resolvins (RvDs), one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions (Molfino et al. 2017). The biosynthesis of RvDs occurs mainly during the process of inflammation when endothelial cells interact with leukocytes. Dietary DHA circulates in plasma or is present in cellular membranes as it can easily integrate into membranes. On injury or infection, DHA moves with edema into the tissue sites of acute inflammation where it is converted to exudate RvDs to interact with local immune cells (Kasuga et al. 2008). The initial transformation of DHA by aspirin-acetylated cyclooxygenase-2 or cyclooxygenase-mediated catalysis can produce stereospecific D-resolvins (18(R)- or 18(S)-RvDs respectively). Combinations of oxidation, reduction and hydrolysis reactions determine the type of D-resolvin formed (RvD1-6) (Serhan et al. 2002, Serhan & Petasis 2011, Serhan et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
12391014	Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL	J. Exp. Med.	2002
25359497	Lipid mediators in the resolution of inflammation Serhan, CN, Levy, BD, Chiang, N, Dalli, J	Cold Spring Harb Perspect Biol	2014
21766791	Resolvins and protectins in inflammation resolution Serhan, CN, Petasis, NA	Chem. Rev.	2011