Reactome | ALOX15 oxidises DHA to 17(S)-Hp-DHA

ALOX15 oxidises DHA to 17(S)-Hp-DHA

Stable Identifier

R-HSA-9020275

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate

ReviewStatus

5/5

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In the absence of aspirin in human whole blood, isolated leukocytes and glial cells, 15-lipoxygenase (ALOX15) can oxygenate docosahexanoic acid (DHA) (Kim et al. 1990) to the 17(S) epimer 17(S)-hydroperoxy-docosahexanoic acid (17(S)-Hp-DHA) (Hong et al. 2003). This intermediate leads to the production of 17(S) epimer D-resolvins (as opposed to aspirin-triggered 17(R) epimer D-resolvins), as well as being the precursor for protectins and the proposed precursor for the production of protectin conjugates in tissue regeneration (PCTRs) and resolvin conjugates in tissue regeneration (RCTRs) (Dalli et al. 2015, Ramon et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
2147774	Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets Karanian, JW, Kim, HY, Salem, N	Prostaglandins	1990
12590139	Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation Serhan, CN, Gronert, K, Devchand, PR, Hong, S, Moussignac, RL	J. Biol. Chem.	2003