ALOX15 oxidises DHA to 17(S)-Hp-DHA

Stable Identifier
R-HSA-9020275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In the absence of aspirin in human whole blood, isolated leukocytes and glial cells, 15-lipoxygenase (ALOX15) can oxygenate docosahexanoic acid (DHA) (Kim et al. 1990) to the 17(S) epimer 17(S)-hydroperoxy-docosahexanoic acid (17(S)-Hp-DHA) (Hong et al. 2003). This intermediate leads to the production of 17(S) epimer D-resolvins (as opposed to aspirin-triggered 17(R) epimer D-resolvins), as well as being the precursor for protectins and the proposed precursor for the production of protectin conjugates in tissue regeneration (PCTRs) and resolvin conjugates in tissue regeneration (RCTRs) (Dalli et al. 2015, Ramon et al. 2016).
Literature References
PubMed ID Title Journal Year
2147774 Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets

Karanian, JW, Kim, HY, Salem, N

Prostaglandins 1990
12590139 Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation

Serhan, CN, Gronert, K, Devchand, PR, Hong, S, Moussignac, RL

J. Biol. Chem. 2003
Participants
Participates
Catalyst Activity

arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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