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Biosynthesis of aspirin-triggered D-series resolvins
Stable Identifier
R-HSA-9020265
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of aspirin-triggered D-series resolvins (Homo sapiens)
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The D-series resolvins (RvD1-6) are biosynthesised from the precursor ω-3 fatty acid docosahexaenoic acid (DHA), either via the lipoxygenase pathway (17(S)-RvDs) or via aspirin-triggered cylcooxygenase catalysis (described here) forming the epimeric 17(R)-RvD1-6 resolvins (Serhan et al. 2014, Bannenberg & Serhan 2010).
Literature References
PubMed ID
Title
Journal
Year
20708099
Specialized pro-resolving lipid mediators in the inflammatory response: An update
Serhan, CN
,
Bannenberg, G
Biochim. Biophys. Acta
2010
25359497
Lipid mediators in the resolution of inflammation
Serhan, CN
,
Levy, BD
,
Chiang, N
,
Dalli, J
Cold Spring Harb Perspect Biol
2014
Participants
Events
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA
(Homo sapiens)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA
(Homo sapiens)
ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA
(Homo sapiens)
Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6
(Homo sapiens)
Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
(Homo sapiens)
ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA
(Homo sapiens)
ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA
(Homo sapiens)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2
(Homo sapiens)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4
(Homo sapiens)
AT-RvD1-6 translocate from cytosol to extracellular region
(Homo sapiens)
Participates
as an event of
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Event Information
Go Biological Process
long-chain fatty acid biosynthetic process (0042759)
Orthologous Events
Biosynthesis of aspirin-triggered D-series resolvins (Bos taurus)
Biosynthesis of aspirin-triggered D-series resolvins (Caenorhabditis elegans)
Biosynthesis of aspirin-triggered D-series resolvins (Canis familiaris)
Biosynthesis of aspirin-triggered D-series resolvins (Danio rerio)
Biosynthesis of aspirin-triggered D-series resolvins (Dictyostelium discoideum)
Biosynthesis of aspirin-triggered D-series resolvins (Drosophila melanogaster)
Biosynthesis of aspirin-triggered D-series resolvins (Gallus gallus)
Biosynthesis of aspirin-triggered D-series resolvins (Mus musculus)
Biosynthesis of aspirin-triggered D-series resolvins (Plasmodium falciparum)
Biosynthesis of aspirin-triggered D-series resolvins (Rattus norvegicus)
Biosynthesis of aspirin-triggered D-series resolvins (Saccharomyces cerevisiae)
Biosynthesis of aspirin-triggered D-series resolvins (Schizosaccharomyces pombe)
Biosynthesis of aspirin-triggered D-series resolvins (Sus scrofa)
Biosynthesis of aspirin-triggered D-series resolvins (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000106
Authored
Jassal, B (2017-09-05)
Reviewed
Hansen, TV (2018-02-21)
Created
Jassal, B (2017-09-05)
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