Biosynthesis of DHA-derived sulfido conjugates

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R-HSA-9026395
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Pathway
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Homo sapiens
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The polyunsaturated fatty acid (PUFA) ω-3 docosahexaenoic acid (DHA) is a precursor for the production of novel sulfido-peptide conjugated mediators with structural similarity to the cysteinyl-leukotrienes and with novel biological properties. They are produced from specialised proresolving mediators (SPMs) in human macrophages and are termed protectin conjugates in tissue regeneration (PCTR), resolvin conjugates in tissue regeneration (RCTR), and maresin conjugates in tissue regeneration (MCTR) because they regulate mechanisms in inflammation resolution as well as tissue regeneration (Dalli et al. 2014, 2015, 2016, Serhan et al. 2017). Their biosynthesis is descibed in this section.

Literature References
PubMed ID Title Journal Year
25324525 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

Dalli, J, Chiang, N, Serhan, CN

Proc. Natl. Acad. Sci. U.S.A. 2014
27791009 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Dalli, J, Vlasakov, I, Riley, IR, Rodriguez, AR, Spur, BW, Petasis, NA, Chiang, N, Serhan, CN

Proc. Natl. Acad. Sci. U.S.A. 2016
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Dalli, J, Ramon, S, Norris, PC, Colas, RA, Serhan, CN

FASEB J. 2015
28802833 New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

Serhan, CN, Chiang, N, Dalli, J

Mol. Aspects Med. 2017
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