Reactome | ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA

ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA

Stable Identifier

R-HSA-9024983

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA

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In macrophages, lipoxygenase 12 (ALOX12:Fe2+) may abstract hydrogen from 14(S)-hydroperoxy-docosaheaenoic acid (14(S)-Hp-DHA) to form 13(S),14(S)-epoxy-DHA (Serhan et al. 2009, Dalli et al. 2013, Deng et al. 2014). This epoxy product is a central intermediate in maresin MaR1 and MaR2 and maresin conjugates in tissue regeneration (MCTR) biosyntheses (Dalli et al. 2016) as well as possessing potent proresolving activity (Dalli et al 2013).

Literature References

PubMed ID	Title	Journal	Year
25036362	Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages Wang, CW, Serhan, CN, Cheng, CY, Arnardottir, HH, Li, Y, Deng, B, Dalli, J	PLoS ONE	2014
23504711	The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype Zhu, M, Serhan, CN, Vlasenko, NA, Haeggström, JZ, Petasis, NA, Deng, B, Dalli, J	FASEB J.	2013
19103881	Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions Kasuga, K, Pillai, PS, Serhan, CN, Spite, M, Oh, SF, Porter, TF, Martinod, K, Yang, R	J. Exp. Med.	2009