ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA

Stable Identifier
Reaction [transition]
Homo sapiens
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In macrophages, lipoxygenase 12 (ALOX12:Fe2+) may abstract hydrogen from 14(S)-hydroperoxy-docosaheaenoic acid (14(S)-Hp-DHA) to form 13(S),14(S)-epoxy-DHA (Serhan et al. 2009, Dalli et al. 2013, Deng et al. 2014). This epoxy product is a central intermediate in maresin MaR1 and MaR2 and maresin conjugates in tissue regeneration (MCTR) biosyntheses (Dalli et al. 2016) as well as possessing potent proresolving activity (Dalli et al 2013).

Literature References
PubMed ID Title Journal Year
25036362 Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages

Wang, CW, Serhan, CN, Cheng, CY, Arnardottir, HH, Li, Y, Deng, B, Dalli, J

PLoS ONE 2014
23504711 The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

Zhu, M, Serhan, CN, Vlasenko, NA, Haeggström, JZ, Petasis, NA, Deng, B, Dalli, J

FASEB J. 2013
19103881 Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

Kasuga, K, Pillai, PS, Serhan, CN, Spite, M, Oh, SF, Porter, TF, Martinod, K, Yang, R

J. Exp. Med. 2009
Catalyst Activity

arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]

Orthologous Events
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