Reactome | ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA

Stable Identifier

R-HSA-9020274

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA

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Maresins are a family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. In the first step, DHA is oxygenated by lipoxygenase 12 using Fe2+ cofactor (ALOX12:Fe2+) to 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) (Serhan et al. 2009, Deng et al. 2014). Maresin-like mediators MaR-L1 and Mar-L2 are produced by leukocytes and platelets and have been shown to restore reparative functions of diabetic macrophages in wounds (Brem & Tomic-Canic 2007, Hong et al. 2014). The same reaction as above can occur in human leukocytes and platelets to produce MaR-L1 and MaR-L2. The 14(S)-Hp-DHA intermediate can also serve as a precursor for maresin conjugates in tissue regeneration (MCTR) (Dalli et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
25036362	Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages Deng, B, Wang, CW, Arnardottir, HH, Li, Y, Cheng, CY, Dalli, J, Serhan, CN	PLoS ONE	2014
19103881	Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions Serhan, CN, Yang, R, Martinod, K, Kasuga, K, Pillai, PS, Porter, TF, Oh, SF, Spite, M	J. Exp. Med.	2009

Participants

Input

Output

14(S)-Hp-DHA [cytosol]

Participates

as an event of

Biosynthesis of DHA-derived SPMs (Homo sapiens)

Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]

Physical Entity

ALOX12:Fe2+ [cytosol] (Homo sapiens)

Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)

Orthologous Events

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Canis familiaris)

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Mus musculus)

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Rattus norvegicus)

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Sus scrofa)