Elongating transcript encounters a lesion in the template

Stable Identifier
R-HSA-113429
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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At the beginning of this reaction, 1 molecule of 'Processive elongation complex' is present. At the end of this reaction, 1 molecule of 'DSIF complex', 1 molecule of 'FACT complex', 1 molecule of 'RNA Polymerase II holoenzyme complex (hyperphosphorylated)', 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid', 1 molecule of 'Elongin Complex', 1 molecule of 'FCP1P protein', 1 molecule of 'P-TEFb complex', 1 molecule of 'NELF complex', 1 molecule of 'RNA polymerase II elongation factor ELL', 1 molecule of 'NTP', 1 molecule of 'TFIIS protein', and 1 molecule of 'TFIIF' are present.

This reaction takes place in the 'nucleus' (Woudstra et al. 2002).

Literature References
PubMed ID Title Journal Year
15489290 Elongation by RNA polymerase II: the short and long of it

Sims, RJ, Belotserkovskaya, R, Reinberg, D

Genes Dev. 2004
11859374 A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage

Woudstra, EC, Gilbert, C, Fellows, J, Jansen, L, Brouwer, J, Erdjument-Bromage, H, Tempst, P, Svejstrup, JQ

Nature 2002
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Created