Reactome | fa93d05 [cytosol]

fa93d05 [cytosol]

Stable Identifier

R-DRE-72452

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL30, Q7ZUG6

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fa93d05 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fa93d05 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fa93d05 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fa93d05 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fa93d05 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fa93d05 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fa93d05 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7ZUG6

Gene Names

fa93d05

Reference Genes

BioGPS Gene:336713 fa93d05

ENSEMBL:ENSDARG00000035871

ENSEMBL:ENSDARG00000035871.7 fa93d05

ENSEMBL:ENSDARG00000109253.1 fa93d05

KEGG Gene (Danio rerio):336713 fa93d05

Monarch:336713 fa93d05

NCBI Gene:336713 fa93d05

Reference Transcript

RefSeq:NM_200028.1 fa93d05

Other Identifiers

13069947

336713

A_15_P117193

A_15_P120175

A_15_P439040

A_15_P741296

BC062278

CJ014436

DRER06418

DRER46368

Dr.645.1.S1_at

ENSDART00000052082

ENSDART00000052082_1

ENSDART00000052082_2

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0022625

GO:0043226

GO:1990904

GT_Spec_NM_200028.1_230735

LOLS11564

MADDr01007694

NM_200028

OTTDART00000019233

OTTDART00000019234

Participates

as a component of

Inferred From

RPL30 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_956322.1

ZFIN

ZDB-GENE-030131-8657

Ensembl

ENSDARG00000035871, ENSDART00000052082, ENSDART00000191699, ENSDARG00000109253, ENSDARP00000154812, ENSDARP00000052081

PDB

7OYB, 7OYA

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