Reactome | OGDH [mitochondrial matrix]

OGDH [mitochondrial matrix]

Stable Identifier

R-MMU-69981

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

mitochondrial matrix

Synonyms

Q60597

Locations in the PathwayBrowser

Expand all

Metabolism (Mus musculus)

- Aerobic respiration and respiratory electron transport (Mus musculus)
  - Citric acid cycle (TCA cycle) (Mus musculus)
    - OGDH complex synthesizes succinyl-CoA from 2-OG (Mus musculus)
      - DLD dimer dehydrogenates dihydrolipoyl (Mus musculus)
        
        OGDH complex [mitochondrial matrix] (Mus musculus)
        
        OGDH dimer [mitochondrial matrix] (Mus musculus)
        
        alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Mus musculus)
        
        OGDH [mitochondrial matrix] (Mus musculus)
      - DLST transfers succinyl to CoA (Mus musculus)
        
        OGDH complex [mitochondrial matrix] (Mus musculus)
        
        OGDH dimer [mitochondrial matrix] (Mus musculus)
        
        alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Mus musculus)
        
        OGDH [mitochondrial matrix] (Mus musculus)
      - OGDH dimer decarboxylates 2-OG (Mus musculus)
        
        OGDH complex [mitochondrial matrix] (Mus musculus)
        
        OGDH dimer [mitochondrial matrix] (Mus musculus)
        
        alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Mus musculus)
        
        OGDH [mitochondrial matrix] (Mus musculus)
        
        OGDH dimer [mitochondrial matrix] (Mus musculus)
        
        alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Mus musculus)
        
        OGDH [mitochondrial matrix] (Mus musculus)
- Metabolism of amino acids and derivatives (Mus musculus)
  - Glyoxylate metabolism and glycine degradation (Mus musculus)
    - Glycine degradation (Mus musculus)
      - DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Mus musculus)
        
        OGDH complex [mitochondrial matrix] (Mus musculus)
        
        OGDH dimer [mitochondrial matrix] (Mus musculus)
        
        alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Mus musculus)
        
        OGDH [mitochondrial matrix] (Mus musculus)

External Reference Information

External Reference

UniProt:Q60597

Reference Genes

BioGPS Gene:18293

ENSEMBL:ENSMUSG00000020456

KEGG:mmu:18293

Monarch:18293

NCBI Gene:18293

UCSC:Q60597

Reference Transcript

Other Identifiers

10374119

107924_at

1445632_at

1451274_at

17247080

18293

4317468

4317611

4321272

4349572

4357039

4412329

4436370

4445049

4445595

4488561

4527761

4595791

4698909

4723396

4726412

4749849

4770920

4773670

4783507

4800036

4808475

4820012

4876532

4898370

4929727

4931064

5006114

5029322

5037838

5073272

5081654

5190841

5234053

5291041

5307884

5313515

5378617

5397935

5408723

5415045

5434000

96879_at

A_51_P122825

A_52_P369310

A_55_P2006280

A_55_P2006281

GE33004

GO:0004591

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0006091

GO:0006096

GO:0006099

GO:0006103

GO:0006104

GO:0006734

GO:0006790

GO:0016491

GO:0016624

GO:0016903

GO:0021695

GO:0021756

GO:0021766

GO:0021794

GO:0021860

GO:0022028

GO:0030976

GO:0031072

GO:0031966

GO:0045252

GO:0046872

GO:0048856

GO:0048870

GO:0051087

GO:0055086

GO:0061034

GO:0120551

GO:1901135

ILMN_2514149

ILMN_2639805

ILMN_2691697

mMC019404

mMC025530

Participates

as a member of

as a component of

alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Mus musculus)

Inferred From

OGDH [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_035086.2, NP_001239217.1, NP_001348832.1, NP_001239211.1, NP_001239212.1, XP_030101509.1, XP_030101508.1, XP_006514647.1, NP_001239216.1, NP_001348833.1, NP_001348831.1, XP_006514645.1

ENSEMBL

ENSMUSP00000091041, ENSMUST00000003461, ENSMUSG00000020456, ENSMUSP00000003461, ENSMUST00000101554, ENSMUSP00000099090, ENSMUST00000093350

IntEnz

1.2.4.2

PRO

Q60597

MGI

1098267

PDB

3TF7, 3E2H