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RIPK1 [cytosol]
Stable Identifier
R-HSA-168651
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Receptor-interacting serine/threonine-protein kinase 1, receptor interacting protein 1 kinase, RIP1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
HSV1 RIR1 binds RIPK1 (Homo sapiens)
HSV1 RIR1:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
RIP1 facilitates IKK complex phosphorylation (Homo sapiens)
dsDNA:ZBP1:RIP1:RIP3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:RIP1:RIP3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
MAVS interacts with RIPK1 and FADD (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Processing of caspases (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Recruitment of IKK complex (Homo sapiens)
dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1, RIP1-mediated IKK complex recruitment (Homo sapiens)
Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TLR3-mediated TICAM1-dependent programmed cell death (Homo sapiens)
Caspase-8 processing within TLR3 complex (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TLR3-induced ripoptosome assembly (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRIF-mediated programmed cell death (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIP3 binds TRIF to mediate necroptosis (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRIF:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TLR4-induced ripoptosome assembly (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)
TNFAIP3:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)
TNFAIP3:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)
USP21:RIPK1,DDX58 [cytosol] (Homo sapiens)
RIPK1, DDX58 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
TNF-mediated dimerization of procaspase-8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK1 is phosphorylated (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK3 is phosphorylated (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Small molecule inhibitor binds RIPK1, RIPK3 (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1 binds STUB1 (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 binds FADD (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13546 RIPK1
Gene Names
RIPK1, RIP, RIP1
Chain
chain:1-671
Reference Genes
BioGPS Gene:8737 RIPK1
COSMIC (genes):RIPK1 RIPK1
CTD Gene:8737 RIPK1
dbSNP Gene:8737 RIPK1
ENSEMBL:ENSG00000137275 RIPK1
HGNC:10019 RIPK1
KEGG:hsa:8737 RIPK1
Monarch:8737 RIPK1
NCBI Gene:8737 RIPK1
OMIM:603453 RIPK1
UCSC:Q13546 RIPK1
Reference Transcript
RefSeq:NM_003804.4 RIPK1
RefSeq:XM_005249457.3 RIPK1
Other Identifiers
11737938_a_at
11737939_a_at
11737940_s_at
11750849_a_at
11756807_a_at
17004295
209941_PM_at
209941_at
226551_PM_at
226551_at
2892343
2892344
2892345
2892346
2892347
2892349
2892350
2892352
2892355
2892356
2892357
2892358
2892359
2892360
2892361
2892362
2892363
2892364
2892365
2892367
2892368
2892372
2892373
2892375
2892376
2892377
2892378
2892379
2892380
2892381
2892382
2892383
2892384
2892385
2892386
2892387
2892388
2892389
2892394
2892395
2892396
2892397
2939059
2939062
2939063
40696_at
475_at
51161_at
8116622
8737
A_23_P370005
A_33_P3279059
GE753557
GO:0000165
GO:0001934
GO:0003824
GO:0004672
GO:0004674
GO:0004706
GO:0005123
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006355
GO:0006468
GO:0006915
GO:0006950
GO:0006954
GO:0006979
GO:0007165
GO:0007166
GO:0010008
GO:0010628
GO:0012501
GO:0016740
GO:0030163
GO:0031264
GO:0031349
GO:0031625
GO:0032757
GO:0032760
GO:0032991
GO:0033209
GO:0034612
GO:0035556
GO:0035591
GO:0036289
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043226
GO:0043235
GO:0043410
GO:0043525
GO:0044877
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0050729
GO:0051092
GO:0060090
GO:0060545
GO:0060546
GO:0062100
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070926
GO:0071345
GO:0071356
GO:0071363
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:0106310
GO:0140096
GO:1900119
GO:1901026
GO:1901224
GO:1903265
GO:1903800
GO:1990000
GO:2000377
GO:2000379
GO:2001237
GO:2001238
GO:2001240
HMNXSV003025407
HMNXSV003028067
Hs.77273.1.A1_3p_at
Hs.77273.1.A1_3p_x_at
ILMN_2119535
PH_hs_0018906
PH_hs_0020922
TC06000023.hg
TC06002463.hg
TC06002466.hg
U50062_at
g3426026_3p_at
Participates
as a component of
dsDNA:ZBP1:RIP1:RIP3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
RIPK1:RIPK3 [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
HSV1 RIR1:RIPK1 [cytosol] (Homo sapiens)
TNFAIP3:RIPK1 [cytosol] (Homo sapiens)
as an input of
Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)
ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)
MAVS interacts with RIPK1 and FADD (Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
RIPK1 binds STUB1 (Homo sapiens)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
HSV1 RIR1 binds RIPK1 (Homo sapiens)
as a member of
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Homo sapiens)
RIPK1, DDX58 [cytosol] (Homo sapiens)
Other forms of this molecule
RIPK1 [endosome membrane]
K63polyUb-RIPK1 [cytosol]
p-S166-RIPK1 [cytosol]
p-S357-RIPK1 [cytosol]
p-S320-RIPK1 [cytosol]
K63,M1polyUb, p-T189-RIPK1 [cytosol]
polyUb-K377,K604,K634-RIPK1 [cytosol]
RIPK1(325-671) [cytosol]
RIPK1(1-324) [cytosol]
K63,M1polyUb-RIPK1 [cytosol]
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
RIPK1 [plasma membrane]
RIPK1 D324H [cytosol]
RIPK1 D324V [cytosol]
RIPK1 D324Y [cytosol]
RIPK1 D324N [cytosol]
PolyUb-RIPK1 [cytosol]
K48polyUb-RIPK1 [cytosol]
Inferred To
Homologues of RIPK1 [cytosol]
(Plasmodium falciparum)
Homologues of RIPK1 [cytosol]
(Xenopus tropicalis)
Ghost homologue of RIPK1 [cytosol]
(Danio rerio)
Ripk1 [cytosol]
(Rattus norvegicus)
RIPK1 [cytosol]
(Bos taurus)
RIPK1 [cytosol]
(Caenorhabditis elegans)
RIPK1 [cytosol]
(Canis familiaris)
RIPK1 [cytosol]
(Drosophila melanogaster)
RIPK1 [cytosol]
(Gallus gallus)
RIPK1 [cytosol]
(Mus musculus)
RIPK1 [cytosol]
(Plasmodium falciparum)
RIPK1 [cytosol]
(Sus scrofa)
RIPK1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005249514.2
,
NP_003795.2
ZINC - World Drugs
RIPK1_HUMAN
Guide to Pharmacology - Targets
2189
OpenTargets
ENSG00000137275
ENSEMBL
ENST00000259808
,
ENSP00000369773
,
ENSP00000259808
,
ENST00000380409
ZINC - FDA approved
RIPK1_HUMAN
ZINC - Substances
RIPK1_HUMAN
ZINC target
Q13546
PRO
Q13546
GlyGen
Q13546
PDB
6C3E
,
6RLN
,
7XMK
,
7YDX
,
5TX5
,
6C4D
,
6AC5
,
8I2N
,
6OCQ
,
6HHO
,
6NW2
,
6R5F
,
7FD0
,
4ITJ
,
5HX6
,
7CJB
,
6NYH
,
5V7Z
,
4ITI
,
7FCZ
,
4NEU
,
4ITH
ZINC - Investigational
RIPK1_HUMAN
HPA
ENSG00000137275-RIPK1
Pharos - Targets
Q13546
ZINC - Predictions - Purchasable
RIPK1_HUMAN
HMDB Protein
HMDBP09499
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y572 RIPK3
8
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
0.972
27
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.959
30
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.928
12
UniProt:Q9Y6K9 IKBKG
12
IKBKG [cytosol]
(R-HSA-168108)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
IKBKG [nucleoplasm]
(R-HSA-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG D406V [cytosol]
(R-HSA-5262943)
0.893
9
UniProt:Q13546 RIPK1
20
RIPK1 [cytosol]
(R-HSA-168651)
RIPK1 [endosome membrane]
(R-HSA-450326)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
RIPK1 [plasma membrane]
(R-HSA-937073)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
0.892
11
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.884
10
UniProt:P19438 TNFRSF1A
2
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(30-45) [plasma membrane]
(R-HSA-5675738)
0.877
7
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.837
9
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.798
8
UniProt:P0DTD1-PRO_0000449629 REP
0.788
6
UniProt:Q13114 TRAF3
4
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
TRAF3 [cytosol]
(R-HSA-914241)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 R118W [cytosol]
(R-HSA-5602321)
0.703
5
UniProt:Q13490 BIRC2
5
BIRC2 [cytosol]
(R-HSA-50847)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
0.697
5
UniProt:Q13489 BIRC3
3
BIRC3 [cytosol]
(R-HSA-50845)
K48pUb-BIRC3 [cytosol]
(R-HSA-5675478)
K63polyUb-BIRC3 [cytosol]
(R-HSA-5668478)
0.602
3
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cilium]
(R-HSA-5632507)
CSNK1A1 [cytosol]
(R-HSA-195263)
0.602
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.589
2
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.564
3
UniProt:P04083 ANXA1
2
ANXA1 [cytosol]
(R-HSA-5263630)
ANXA1 [extracellular region]
(R-HSA-444539)
0.556
5
IntAct:EBI-4399559 UBIQ
0.544
3
UniProt:Q8IVM0 CCD50
0.524
2
UniProt:Q13107 USP4
1
USP4 [cytosol]
(R-HSA-5212663)
0.524
4
UniProt:O00635 TRIM38
1
TRIM38 [cytosol]
(R-HSA-5624325)
0.508
2
UniProt:B7UI21 NLEB1
0.508
4
UniProt:U5TQE9 U5TQE9
0.499
3
UniProt:Q96AB6 NTAN1
0.499
2
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