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K63polyUb-RIPK1 [cytosol]
Stable Identifier
R-HSA-937021
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-RIP1, K63-linked polyUb - RIP1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1, RIP1-mediated IKK complex recruitment (Homo sapiens)
IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)
activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane] (Homo sapiens)
activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
TRIF-mediated programmed cell death (Homo sapiens)
TLR4-induced ripoptosome assembly (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)
TNFAIP3:K63polyUb-RIPK1 [cytosol] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Homo sapiens)
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Homo sapiens)
K63polyUb-RIPK1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16603398
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
Ea, CK
,
Deng, L
,
Xia, ZP
,
Pineda, G
,
Chen, ZJ
Mol Cell
2006
External Reference Information
External Reference
UniProt:Q13546 RIPK1
Gene Names
RIPK1, RIP, RIP1
Chain
chain:1-671
Reference Genes
BioGPS Gene:8737 RIPK1
COSMIC (genes):RIPK1 RIPK1
CTD Gene:8737 RIPK1
dbSNP Gene:8737 RIPK1
ENSEMBL:ENSG00000137275 RIPK1
HGNC:10019 RIPK1
KEGG Gene (Homo sapiens):8737 RIPK1
Monarch:8737 RIPK1
NCBI Gene:8737 RIPK1
OMIM:603453 RIPK1
UCSC:Q13546 RIPK1
Reference Transcript
RefSeq:XM_005249457.3 RIPK1
RefSeq:NM_003804.4 RIPK1
Other Identifiers
0006520154
11737938_a_at
11737939_a_at
11737940_s_at
11750849_a_at
11756807_a_at
17004295
209941_at
226551_at
2892345
2892349
2892350
2892352
2892355
2892356
2892357
2892358
2892359
2892363
2892364
2892372
2892373
2892375
2892376
2892377
2892378
2892379
2892383
2892385
2892386
2892387
2892388
2892389
40696_at
475_at
51161_at
8116622
8737
A_23_P370005
A_33_P3279059
GO:0000166
GO:0000278
GO:0001934
GO:0002376
GO:0002756
GO:0003674
GO:0004672
GO:0004674
GO:0004706
GO:0005123
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006919
GO:0006950
GO:0006954
GO:0007049
GO:0007165
GO:0007249
GO:0007256
GO:0007257
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0010008
GO:0010803
GO:0010940
GO:0010942
GO:0012501
GO:0016020
GO:0016032
GO:0016301
GO:0016310
GO:0016579
GO:0016740
GO:0019899
GO:0022607
GO:0030154
GO:0031264
GO:0031410
GO:0031625
GO:0032757
GO:0032760
GO:0032991
GO:0033209
GO:0034138
GO:0034612
GO:0034641
GO:0035666
GO:0036289
GO:0040007
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043167
GO:0043226
GO:0043235
GO:0043410
GO:0044257
GO:0044403
GO:0044877
GO:0045121
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0048856
GO:0050729
GO:0051092
GO:0055085
GO:0060044
GO:0060545
GO:0060546
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070926
GO:0071356
GO:0071363
GO:0071550
GO:0097190
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:1901026
GO:1902041
GO:1902042
GO:1903265
GO:1903800
GO:1905206
GO:1990000
GO:2000134
GO:2000377
GO:2000379
GO:2001237
GO:2001238
GO:2001240
Hs.77273.1.A1_3p_at
Hs.77273.1.A1_3p_x_at
ILMN_1657937
ILMN_2119535
PH_hs_0018906
TC06000023.hg
TC06002463.hg
U50062_at
g3426026_3p_at
Participant Of
hasComponent
activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane]
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
TNFAIP3:K63polyUb-RIPK1 [cytosol]
hasMember
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]
Other forms of this molecule
K48polyUb-RIPK1 [cytosol]
PolyUb-RIPK1 [cytosol]
RIPK1 D324N [cytosol]
RIPK1 D324Y [cytosol]
RIPK1 D324V [cytosol]
RIPK1 D324H [cytosol]
RIPK1 [plasma membrane]
K63pUb-K377-RIP1 [cytosol]
RIPK1(1-324) [cytosol]
RIPK1(325-671) [cytosol]
p-S166-RIPK1 [cytosol]
RIPK1 [endosome membrane]
RIPK1 [cytosol]
Inferred To
arkA [cytosol] (Dictyostelium discoideum)
ripk1l [cytosol] (Danio rerio)
ripk1 [cytosol] (Xenopus tropicalis)
K63polyUb-RIPK1 [cytosol] (Dictyostelium discoideum)
K63polyUb-RIPK1 [cytosol] (Sus scrofa)
Takl1 [cytosol] (Drosophila melanogaster)
Ripk1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Rattus norvegicus)
Homologues of K63polyUb-RIPK1 [cytosol] (Dictyostelium discoideum)
RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Gallus gallus)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 377
Coordinate
377
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_003795.2
,
XP_005249514.2
ZINC - World Drugs
RIPK1_HUMAN
OpenTargets
ENSG00000137275
ZINC - FDA approved
RIPK1_HUMAN
ZINC - Substances
RIPK1_HUMAN
ZINC target
Q13546
PRO
Q13546
PDB
6C4D
,
6OCQ
,
4ITH
,
5HX6
,
4ITJ
,
6HHO
,
5TX5
,
6AC5
,
6NW2
,
4ITI
,
6NYH
,
6C3E
,
5V7Z
,
6R5F
,
6RLN
,
4NEU
ZINC - Investigational
RIPK1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000137275-RIPK1
GeneCards
Q13546
Ensembl
ENSP00000369773
,
ENST00000380409
,
ENSP00000259808
,
ENST00000259808
,
ENSG00000137275
ZINC - Predictions - Purchasable
RIPK1_HUMAN
HMDB Protein
HMDBP09499
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14790 CASP8
8
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(217-374) [cytosol]
(R-HSA-75975)
0.956
29
UniProt:Q9Y572 RIPK3
7
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
RIPK3 [cytosol]
(R-HSA-450328)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
0.949
26
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.893
9
UniProt:Q13546 RIPK1
14
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K63pUb-K377-RIP1 [cytosol]
(R-HSA-5212672)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.892
11
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.884
10
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.866
10
UniProt:P19438 TNFRSF1A
3
TNFRSF1A [plasma membrane]
(R-HSA-5675738)
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(22-455) [plasma membrane]
(R-HSA-66344)
0.839
6
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.837
9
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.798
8
UniProt:Q13114 TRAF3
5
K48polyUb-TRAF3 [cytosol]
(R-HSA-5668444)
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.703
5
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2 [cytosol]
(R-HSA-50847)
0.697
5
UniProt:Q13489 BIRC3
3
K48pUb-BIRC3 [cytosol]
(R-HSA-5675478)
BIRC3 [cytosol]
(R-HSA-50845)
K63polyUb-BIRC3 [cytosol]
(R-HSA-5668478)
0.602
3
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cilium]
(R-HSA-5632507)
CSNK1A1 [cytosol]
(R-HSA-195263)
0.602
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.589
2
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.564
3
UniProt:P04083 ANXA1
2
ANXA1 [extracellular region]
(R-HSA-444539)
ANXA1 [cytosol]
(R-HSA-5263630)
0.556
5
IntAct:EBI-4399559 UBIQ
0.544
3
UniProt:P0DTD1-PRO_0000449629 REP
0.527
2
UniProt:Q8IVM0 CCD50
0.524
2
UniProt:Q13107 USP4
1
USP4 [cytosol]
(R-HSA-5212663)
0.524
4
UniProt:O00635 TRIM38
1
TRIM38 [cytosol]
(R-HSA-5624325)
0.508
2
UniProt:B7UI21 B7UI21
0.508
4
UniProt:U5TQE9 U5TQE9
0.499
3
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