K63polyUb-RIPK1

Stable Identifier
R-HSA-937021
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
K63polyUb-RIP1, K63-linked polyUb - RIP1
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
16603398 Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

Ea, CK, Deng, L, Xia, ZP, Pineda, G, Chen, ZJ

Mol Cell 2006
External Reference Information
External Reference
Gene Names
RIPK1, RIP, RIP1
Chain
chain:1-671
Other Identifiers
0006520154
10302
11737938_a_at
11737939_a_at
11737940_s_at
11750849_a_at
11756807_a_at
15257
17004295
209941_at
226551_at
2892345
2892349
2892350
2892352
2892355
2892356
2892357
2892358
2892359
2892363
2892364
2892372
2892373
2892375
2892376
2892377
2892378
2892379
2892383
2892385
2892386
2892387
2892388
40696_at
475_at
4ITH
4ITI
4ITJ
4NEU
51161_at
5HX6
5TX5
8116622
8737
A0A024QZU0
A_23_P370005
A_33_P3279059
AAC32232
AAC50137
AAI26255
AAI26257
AAT74626
AB208926
AK304701
AK314176
AL031963
AY682848
BAD92163
BAG36858
BAG65471
BC126254
BC126256
CAB010302
CAD70625
CCDS4482
CH471087
EAW55115
EAW55117
ENSG00000137275
ENSP00000259808
ENSP00000369773
ENST00000259808
ENST00000380409
EntrezGene:8737
g3426026_3p_at
GO:0000166
GO:0001934
GO:0002376
GO:0002756
GO:0003674
GO:0004672
GO:0004674
GO:0004871
GO:0005123
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006461
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006919
GO:0006950
GO:0007165
GO:0007249
GO:0007257
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0010008
GO:0010803
GO:0010940
GO:0010942
GO:0012501
GO:0016020
GO:0016032
GO:0016301
GO:0016310
GO:0016579
GO:0016740
GO:0019899
GO:0022607
GO:0030154
GO:0031264
GO:0031410
GO:0031625
GO:0032757
GO:0032760
GO:0033209
GO:0034138
GO:0034612
GO:0034641
GO:0035666
GO:0036289
GO:0042327
GO:0042802
GO:0043065
GO:0043068
GO:0043123
GO:0043124
GO:0043167
GO:0043226
GO:0043234
GO:0043235
GO:0043410
GO:0044257
GO:0044403
GO:0044877
GO:0045121
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0048856
GO:0051092
GO:0051260
GO:0051291
GO:0055085
GO:0060544
GO:0060545
GO:0065003
GO:0070231
GO:0070266
GO:0070513
GO:0070926
GO:0071356
GO:0071363
GO:0071550
GO:0097190
GO:0097191
GO:0097296
GO:0097342
GO:0097343
GO:0097527
GO:1901026
GO:1902041
GO:1902042
GO:1905206
GO:1990000
GO:2000377
GO:2000379
GO:2001237
GO:2001238
GO:2001240
HGNC:10019
HPA015257
Hs.77273.1.A1_3p_at
Hs.77273.1.A1_3p_x_at
ILMN_1657937
ILMN_2119535
IPR000488
IPR000719
IPR001245
IPR008271
IPR011009
IPR011029
IPR025735
NM_001317061
NM_001354930
NM_003804
NP_001303990
NP_001341859
NP_003795
PF00531
PF07714
PF12721
PH_hs_0018906
PR00109
RIPK1
RIPK1-201
RIPK1-202
SM00005
SM00220
TC06000023.hg
TC06002463.hg
U25994
U50062
U50062_at
uc003mux.4
uc063llv.1
UPI000000DC95
XM_005249457
XM_017011403
XP_005249514
XP_016866892
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 377
Coordinate
377
Modification
K63polyUb [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
GeneCards
DOCK Blaster
ZINC target
PRO
BRENDA (Homo sapiens)
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (21)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q14790 CASP8  8 0.956 29
 UniProt:Q9Y572 RIPK3  2 0.949 26
 UniProt:Q13546 RIPK1  9 0.886 10
 UniProt:Q9Y6K9 IKBKG  12 0.858 8
 UniProt:P19438 TNFRSF1A  3 0.839 6
 UniProt:P01375 TNF  5 0.837 9
 UniProt:Q12933 TRAF2  5 0.837 8
 UniProt:Q13158 FADD  1 0.809 9
 UniProt:Q13077 TRAF1  3 0.786 7
 UniProt:Q13114 TRAF3  5 0.675 4
 UniProt:Q13489 BIRC3  3 0.602 3
 UniProt:Q13490 BIRC2  5 0.602 3
 UniProt:P48729 CSNK1A1  2 0.602 5
 UniProt:P08238 HSP90AB1  5 0.589 2
 UniProt:P04083 ANXA1  2 0.556 5
 IntAct:EBI-4399559 UBIQ      0.544 3
 UniProt:Q8IVM0 CCD50      0.524 2
 UniProt:Q13107 USP4  1 0.524 4
 UniProt:O00635 TRIM38  1 0.508 2
 UniProt:B7UI21 B7UI21      0.508 4
 UniProt:U5TQE9 U5TQE9      0.499 3