Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
p-T12-HIST2H3A
Stable Identifier
R-HSA-5625871
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with p-T12-H3 [nucleoplasm] (Homo sapiens)
p-T12-H3 [nucleoplasm] (Homo sapiens)
p-T12-HIST2H3A [nucleoplasm] (Homo sapiens)
PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with p-T12-H3 [nucleoplasm] (Homo sapiens)
p-T12-H3 [nucleoplasm] (Homo sapiens)
p-T12-HIST2H3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q71DI3 HIST2H3A
Gene Names
HIST2H3A, HIST2H3C, H3F2, H3FM, HIST2H3D
Chain
chain:1-136
Reference Genes
BioGPS Gene:126961 HIST2H3A
BioGPS Gene:333932 HIST2H3A
BioGPS Gene:653604 HIST2H3A
COSMIC (genes):HIST2H3A HIST2H3A
CTD Gene:126961 HIST2H3A
CTD Gene:333932 HIST2H3A
CTD Gene:653604 HIST2H3A
dbSNP Gene:126961 HIST2H3A
dbSNP Gene:333932 HIST2H3A
dbSNP Gene:653604 HIST2H3A
ENSEMBL:ENSG00000183598 HIST2H3D
ENSEMBL:ENSG00000203811 HIST2H3C
ENSEMBL:ENSG00000203852 HIST2H3A
HGNC:20503 HIST2H3A
HGNC:20505 HIST2H3A
HGNC:25311 HIST2H3A
KEGG Gene (Homo sapiens):HIST2H3C HIST2H3A
KEGG Gene (Homo sapiens):hsa:126961 HIST2H3A
KEGG Gene (Homo sapiens):hsa:333932 HIST2H3A
KEGG Gene (Homo sapiens):hsa:653604 HIST2H3A
Monarch:126961 HIST2H3A
Monarch:333932 HIST2H3A
Monarch:653604 HIST2H3A
NCBI Gene:126961 HIST2H3A
NCBI Gene:333932 HIST2H3A
NCBI Gene:653604 HIST2H3A
OMIM:142780 HIST2H3A
UCSC:Q71DI3 HIST2H3A
Reference Transcript
RefSeq:NM_001123375.2 HIST2H3A
RefSeq:NM_021059.2 HIST2H3A
RefSeq:NM_001005464.2 HIST2H3A
Other Identifiers
0001050152
11734913_s_at
11742410_s_at
11758569_s_at
126961
16670387
16692614
16692616
2357940
2357941
2357942
2434042
2434043
2434044
2434045
2434046
2434047
2434081
2434082
2434100
2434127
2459531
2IIJ
2X4W
2X4X
2X4Y
333932
3AV1
3DB3
3MO8
3QO2
3R93
42570
4MZF
4MZG
4MZH
4OUC
5B0Y
5B0Z
5B40
5BO0
5CIU
5VAC
653604
69102_at
71712_at
7905085
7919584
7919589
7919606
7919612
7919614
A_23_P115375
A_23_P435029
A_24_P324465
A_24_P45651
A_33_P3229239
A_33_P3229241
A_33_P3257678
ADDON002755.hg
ADDON002789.hg
CCDS30848
CCDS30850
CCDS41388
ENSG00000183598
ENSG00000203811
ENSG00000203852
ENSP00000333277
ENSP00000358154
ENSP00000385479
ENST00000331491
ENST00000369158
ENST00000403683
EntrezGene:126961
EntrezGene:333932
EntrezGene:653604
GE79559
GO:0000122
GO:0000183
GO:0000785
GO:0000786
GO:0003677
GO:0003682
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006334
GO:0007596
GO:0031492
GO:0038111
GO:0042393
GO:0044267
GO:0045652
GO:0045814
GO:0045815
GO:0046982
GO:0060964
GO:0070062
GO:1902036
HGNC:20503
HGNC:20505
HGNC:25311
HIST2H3A
HIST2H3A-201
HIST2H3C
HIST2H3C-201
HIST2H3D
HIST2H3D-201
HPA042570
ILMN_1664706
ILMN_1666179
ILMN_1670093
ILMN_3243527
ILMN_3249188
MIM:142780
NM_001005464
NM_001123375
NM_021059
NP_001005464
NP_001116847
NP_066403
PF00125
PH_hs_0030802
PH_hs_0034534
PH_hs_0036206
PR00622
SM00428
TC01001175.hg
TC01003173.hg
TC01003188.hg
TC01003189.hg
TC01005805.hg
uc001esv.4
uc001esy.4
uc010pbl.3
UPI0000000586
Participant Of
hasMember
p-T12-H3 [nucleoplasm]
Other forms of this molecule
HIST2H3A [extracellular region]
MeK-HIST2H3A [nucleoplasm]
2xAcK-HIST2H3A [nucleoplasm]
Ack10-HIST2H3A [nucleoplasm]
AcK24-HIST2H3A [nucleoplasm]
AcK19-HIST2H3A [nucleoplasm]
AcK15-HIST2H3A [nucleoplasm]
AcK5-HIST2H3A [nucleoplasm]
Ack15-HIST2H3A [nucleoplasm]
Me2aR27-HIST2H3A [nucleoplasm]
MeR27-HIST2H3A [nucleoplasm]
Me2aR18-HIST2H3A [nucleoplasm]
Me2sR9-HIST2H3A [nucleoplasm]
Me2sR3-HIST2H3A [nucleoplasm]
Me3K10-HIST2H3A [nucleoplasm]
Me3K28-HIST2H3A [nucleoplasm]
Me2K28-HIST2H3A [nucleoplasm]
Me2K10-HIST2H3A [nucleoplasm]
MeK37-HIST2H3A [nucleoplasm]
MeK80-HIST2H3A [nucleoplasm]
Me3K80-HIST2H3A [nucleoplasm]
Me2K80-HIST2H3A [nucleoplasm]
Me3K37-HIST2H3A [nucleoplasm]
Me2K37-HIST2H3A [nucleoplasm]
MeK10-HIST2H3A [nucleoplasm]
MeK28-HIST2H3A [nucleoplasm]
MeK10-HIST2H3A [cytosol]
HIST2H3A [cytosol]
Me2aR3-HIST2H3A [nucleoplasm]
MeK5-HIST2H3A [nucleoplasm]
AcK9,14-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
AcK14,18-p-T11-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
Cit27-HIST2H3A [nucleoplasm]
Cit9-HIST2H3A [nucleoplasm]
Cit18-HIST2H3A [nucleoplasm]
MeR18-HIST2H3A [nucleoplasm]
MeR3-HIST2H3A [nucleoplasm]
MeR27-HIST2H3A [nucleoplasm]
MeR9-HIST2H3A [nucleoplasm]
Me2K-10-HIST2H3A [nucleoplasm]
p-T12,MeK-HIST2H3A [nucleoplasm]
Me3K-10-HIST2H3A [nucleoplasm]
p-T12, Me2K-10-HIST2H3A [nucleoplasm]
p-T12, Me3K-10-HIST2H3A [nucleoplasm]
HIST2H3A [nucleoplasm]
Me3K-28-HIST2H3A [nucleoplasm]
Me3K5-HIST2H3A [nucleoplasm]
Me2K5,Me2aR3-HIST2H3A [nucleoplasm]
Me2K5-HIST2H3A [nucleoplasm]
Inferred To
phospho-p-T12-HIST2H3A [nucleoplasm] (Drosophila melanogaster)
phospho-p-T12-HIST2H3A [nucleoplasm] (Mus musculus)
phospho-p-T12-HIST2H3A [nucleoplasm] (Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 12
Coordinate
12
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001005464.1
,
NP_066403.2
,
NP_001116847.1
Brenda
3.6.4.12
GeneCards
Q71DI3
DOCK Blaster
3AV1
,
5VAC
,
3DB3
,
5CIU
,
4MZF
,
3MO8
,
4MZG
,
3R93
,
4MZH
,
2X4Y
,
4OUC
,
2X4X
,
5B40
,
5B0Y
,
2X4W
,
3QO2
,
5B0Z
,
5BO0
PRO
Q71DI3
PDB
2X4Y
,
5CIU
,
3R93
,
5B0Y
,
3AV1
,
5VAC
,
4MZF
,
2IIJ
,
5B0Z
,
3DB3
,
4MZG
,
2X4W
,
5B40
,
3MO8
,
4OUC
,
3QO2
,
5BO0
,
2X4X
,
4MZH
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 HIST1H4A
19
SUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
HIST1H4A [extracellular region]
(R-HSA-977569)
SUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-4568749)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
MeK-HIST1H4A [nucleoplasm]
(R-HSA-2172676)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
0.602
3
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.576
5
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.576
4
© 2018
Reactome