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p-T12, Me3K-10-HIST2H3A [nucleoplasm]
Stable Identifier
R-HSA-5625754
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H3.2 with trimethylated lysine9 (H3K9) and phosphorylated Thr11 (H3T11)
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q71DI3 H3C15
Gene Names
H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D
Chain
chain:1-136
Reference Genes
BioGPS Gene:126961 H3C15
BioGPS Gene:333932 H3C15
BioGPS Gene:653604 H3C15
CTD Gene:126961 H3C15
CTD Gene:333932 H3C15
CTD Gene:653604 H3C15
dbSNP Gene:126961 H3C15
dbSNP Gene:333932 H3C15
dbSNP Gene:653604 H3C15
ENSEMBL:ENSG00000183598 HIST2H3D
ENSEMBL:ENSG00000203811 HIST2H3C
ENSEMBL:ENSG00000203852 HIST2H3A
HGNC:20503 H3C15
HGNC:20505 H3C15
HGNC:25311 H3C15
KEGG Gene (Homo sapiens):126961 H3C15
KEGG Gene (Homo sapiens):333932 H3C15
KEGG Gene (Homo sapiens):653604 H3C15
Monarch:126961 H3C15
Monarch:333932 H3C15
Monarch:653604 H3C15
NCBI Gene:126961 H3C15
NCBI Gene:333932 H3C15
NCBI Gene:653604 H3C15
OMIM:142780 H3C15
UCSC:Q71DI3 H3C15
Reference Transcript
RefSeq:NM_021059.2 H3C15
RefSeq:NM_001005464.2 H3C15
RefSeq:NM_001123375.2 H3C15
Other Identifiers
0001050152
11742410_s_at
126961
16670387
16692614
16692616
2357940
2357941
2357942
2434047
2434081
2434082
333932
653604
7905085
7919589
7919612
7919614
ADDON002755.hg
ADDON002789.hg
A_23_P115375
A_23_P435029
A_24_P324465
A_24_P45651
A_33_P3257678
GE79559
GO:0000183
GO:0000786
GO:0002376
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006334
GO:0006950
GO:0007165
GO:0007596
GO:0008150
GO:0009058
GO:0022607
GO:0030154
GO:0032991
GO:0034641
GO:0038111
GO:0043226
GO:0044267
GO:0045652
GO:0045814
GO:0046982
GO:0048856
GO:0051276
GO:0060964
GO:0065003
GO:0070062
HMNXSV003021896
HMNXSV003029395
ILMN_1664706
ILMN_1666179
ILMN_3243527
ILMN_3249188
PH_hs_0030802
PH_hs_0034534
TC01001175.hg
TC01003173.hg
TC01003188.hg
TC01003189.hg
Participates
as a member of
p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HIST2H3A [extracellular region]
MeK-HIST2H3A [nucleoplasm]
2xAcK-HIST2H3A [nucleoplasm]
AcK24-HIST2H3A [nucleoplasm]
AcK19-HIST2H3A [nucleoplasm]
AcK15-HIST2H3A [nucleoplasm]
AcK5-HIST2H3A [nucleoplasm]
Ack15-HIST2H3A [nucleoplasm]
Me2aR27-HIST2H3A [nucleoplasm]
MeR27-HIST2H3A [nucleoplasm]
Me2aR18-HIST2H3A [nucleoplasm]
Me2sR9-HIST2H3A [nucleoplasm]
Me2sR3-HIST2H3A [nucleoplasm]
AcK9,14-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
AcK14,18-p-T11-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
Me3K10-HIST2H3A [nucleoplasm]
Me3K28-HIST2H3A [nucleoplasm]
Me2K28-HIST2H3A [nucleoplasm]
Me2K10-HIST2H3A [nucleoplasm]
MeK37-HIST2H3A [nucleoplasm]
MeK80-HIST2H3A [nucleoplasm]
Me3K80-HIST2H3A [nucleoplasm]
Me2K80-HIST2H3A [nucleoplasm]
Me3K37-HIST2H3A [nucleoplasm]
Me2K37-HIST2H3A [nucleoplasm]
MeK10-HIST2H3A [nucleoplasm]
MeK28-HIST2H3A [nucleoplasm]
MeK10-HIST2H3A [cytosol]
HIST2H3A [cytosol]
Me2aR3-HIST2H3A [nucleoplasm]
MeK5-HIST2H3A [nucleoplasm]
Cit27-HIST2H3A [nucleoplasm]
Cit9-HIST2H3A [nucleoplasm]
Cit18-HIST2H3A [nucleoplasm]
MeR18-HIST2H3A [nucleoplasm]
MeR3-HIST2H3A [nucleoplasm]
MeR27-HIST2H3A [nucleoplasm]
MeR9-HIST2H3A [nucleoplasm]
Ack10-HIST2H3A [nucleoplasm]
Me2K5,Me2aR3-HIST2H3A [nucleoplasm]
Me2K-10-HIST2H3A [nucleoplasm]
p-T12-HIST2H3A [nucleoplasm]
p-T12,MeK-HIST2H3A [nucleoplasm]
Me3K-10-HIST2H3A [nucleoplasm]
p-T12, Me2K-10-HIST2H3A [nucleoplasm]
Me3K5-HIST2H3A [nucleoplasm]
HIST2H3A [nucleoplasm]
Me3K-28-HIST2H3A [nucleoplasm]
Me2K5-HIST2H3A [nucleoplasm]
Inferred To
phospho-H3C13 [nucleoplasm]
(Canis familiaris)
phospho-H3-VII [nucleoplasm]
(Gallus gallus)
phospho-Hist2h3c2 [nucleoplasm]
(Rattus norvegicus)
phospho-H3c4 [nucleoplasm]
(Mus musculus)
phospho-p-T12, Me3K-10-HIST2H3A [nucleoplasm]
(Danio rerio)
phospho-p-T12, Me3K-10-HIST2H3A [nucleoplasm]
(Sus scrofa)
phospho-p-T12, Me3K-10-HIST2H3A [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
N6,N6,N6-trimethyl-L-lysine at 10
Coordinate
10
PsiMod Name
N6,N6,N6-trimethyl-L-lysine [MOD:00083]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.
Name
O-phospho-L-threonine at 12
Coordinate
12
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_066403.2
,
NP_001116847.1
,
NP_001005464.1
Target Pathogen
57c0ab45be737e1cc0a9d2f0
,
57c5e634be737e5a0cb4cb11
,
57c5eaa7be737e5a0cb4f982
,
5b2801b3be737e35a6deea80
,
57cdcfdfbe737e0b49b9a3bb
,
5b2801b2be737e35a6dea64d
,
57c08b76be737e1cc0a95c6a
,
5b2801b3be737e35a6df0ddc
,
5b2801b3be737e35a6df0ac2
,
5b2801b3be737e35a6df0c8a
,
5b2801b3be737e35a6df1873
,
5b354852be737e166372eaa9
,
5b354852be737e166372e85a
,
5b2801b2be737e35a6de88ae
,
5b2801b2be737e35a6dea9b5
,
57c0ab9bbe737e1cc0a9d7f0
,
5b2801b3be737e35a6dee562
,
5b354852be737e166372e957
,
5b2801b2be737e35a6de9484
,
5b354852be737e166372eb9b
,
5b354852be737e166372eaa2
,
57c0aa24be737e1cc0a9c2e3
,
5b2801b2be737e35a6dea8d6
OpenTargets
ENSG00000203852
GeneCards
Q71DI3
HPA
ENSG00000203811-HIST2H3C
,
ENSG00000183598-HIST2H3D
,
ENSG00000203852-HIST2H3A
Ensembl
ENSP00000385479
,
ENST00000403683
,
ENST00000331491
,
ENSG00000183598
,
ENSP00000333277
,
ENSP00000358154
,
ENSG00000203852
,
ENSG00000203811
,
ENST00000369158
PRO
Q71DI3
PDB
5B40
,
2X4W
,
6T79
,
5CIU
,
7BU9
,
4MZG
,
6X5A
,
3R93
,
4MZH
,
4OUC
,
2IIJ
,
5B0Z
,
6T7D
,
6FML
,
6X59
,
3DB3
,
4MZF
,
3MO8
,
6ACE
,
5B0Y
,
6T7C
,
3QO2
,
7JOA
,
6T7B
,
7BQZ
,
2X4Y
,
7JO9
,
6XJD
,
5BO0
,
6T7A
,
2X4X
,
6Y5E
,
3AV1
,
6Y5D
,
5VAC
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
19
SUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
HIST1H4A [extracellular region]
(R-HSA-977569)
SUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-4568749)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
MeK-HIST1H4A [nucleoplasm]
(R-HSA-2172676)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
0.704
4
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.576
4
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.576
5
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:P29474 NOS3
7
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
NOS3 [cytosol]
(R-HSA-202114)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
0.556
3
UniProt:P14136 GFAP
3
GFAP [lysosomal membrane]
(R-HSA-9625195)
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
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