Reactome | p-T12, Me3K-10-HIST2H3A [nucleoplasm]

p-T12, Me3K-10-HIST2H3A [nucleoplasm]

Stable Identifier

R-HSA-5625754

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H3.2 with trimethylated lysine9 (H3K9) and phosphorylated Thr11 (H3T11)

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
        
        Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q71DI3 H3C15

Gene Names

H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D

Chain

chain:1-136

Reference Genes

BioGPS Gene:126961 H3C15

BioGPS Gene:333932 H3C15

BioGPS Gene:653604 H3C15

CTD Gene:126961 H3C15

CTD Gene:333932 H3C15

CTD Gene:653604 H3C15

dbSNP Gene:126961 H3C15

dbSNP Gene:333932 H3C15

dbSNP Gene:653604 H3C15

ENSEMBL:ENSG00000183598 HIST2H3D

ENSEMBL:ENSG00000203811 HIST2H3C

ENSEMBL:ENSG00000203852 HIST2H3A

HGNC:20503 H3C15

HGNC:20505 H3C15

HGNC:25311 H3C15

KEGG Gene (Homo sapiens):126961 H3C15

KEGG Gene (Homo sapiens):333932 H3C15

KEGG Gene (Homo sapiens):653604 H3C15

Monarch:126961 H3C15

Monarch:333932 H3C15

Monarch:653604 H3C15

NCBI Gene:126961 H3C15

NCBI Gene:333932 H3C15

NCBI Gene:653604 H3C15

OMIM:142780 H3C15

UCSC:Q71DI3 H3C15

Reference Transcript

Other Identifiers

0001050152

11742410_s_at

126961

16670387

16692614

16692616

2357940

2357941

2357942

2434047

2434081

2434082

333932

653604

7905085

7919589

7919612

7919614

ADDON002755.hg

ADDON002789.hg

A_23_P115375

A_23_P435029

A_24_P324465

A_24_P45651

A_33_P3257678

GE79559

GO:0000183

GO:0000786

GO:0002376

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0006950

GO:0007165

GO:0007596

GO:0008150

GO:0009058

GO:0022607

GO:0030154

GO:0032991

GO:0034641

GO:0038111

GO:0043226

GO:0044267

GO:0045652

GO:0045814

GO:0046982

GO:0048856

GO:0051276

GO:0060964

GO:0065003

GO:0070062

HMNXSV003021896

HMNXSV003029395

ILMN_1664706

ILMN_1666179

ILMN_3243527

ILMN_3249188

PH_hs_0030802

PH_hs_0034534

TC01001175.hg

TC01003173.hg

TC01003188.hg

TC01003189.hg

Participates

as a member of

p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST2H3A [extracellular region]

MeK-HIST2H3A [nucleoplasm]

2xAcK-HIST2H3A [nucleoplasm]

AcK24-HIST2H3A [nucleoplasm]

AcK19-HIST2H3A [nucleoplasm]

AcK15-HIST2H3A [nucleoplasm]

AcK5-HIST2H3A [nucleoplasm]

Ack15-HIST2H3A [nucleoplasm]

Me2aR27-HIST2H3A [nucleoplasm]

MeR27-HIST2H3A [nucleoplasm]

Me2aR18-HIST2H3A [nucleoplasm]

Me2sR9-HIST2H3A [nucleoplasm]

Me2sR3-HIST2H3A [nucleoplasm]

AcK9,14-p-S10-HIST2H3A [nucleoplasm]

AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]

AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]

AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]

AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]

AcK14,18-p-S10-HIST2H3A [nucleoplasm]

AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]

AcK14,18-p-T11-HIST2H3A [nucleoplasm]

AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]

Me3K10-HIST2H3A [nucleoplasm]

Me3K28-HIST2H3A [nucleoplasm]

Me2K28-HIST2H3A [nucleoplasm]

Me2K10-HIST2H3A [nucleoplasm]

MeK37-HIST2H3A [nucleoplasm]

MeK80-HIST2H3A [nucleoplasm]

Me3K80-HIST2H3A [nucleoplasm]

Me2K80-HIST2H3A [nucleoplasm]

Me3K37-HIST2H3A [nucleoplasm]

Me2K37-HIST2H3A [nucleoplasm]

MeK10-HIST2H3A [nucleoplasm]

MeK28-HIST2H3A [nucleoplasm]

MeK10-HIST2H3A [cytosol]

HIST2H3A [cytosol]

Me2aR3-HIST2H3A [nucleoplasm]

MeK5-HIST2H3A [nucleoplasm]

Cit27-HIST2H3A [nucleoplasm]

Cit9-HIST2H3A [nucleoplasm]

Cit18-HIST2H3A [nucleoplasm]

MeR18-HIST2H3A [nucleoplasm]

MeR3-HIST2H3A [nucleoplasm]

MeR27-HIST2H3A [nucleoplasm]

MeR9-HIST2H3A [nucleoplasm]

Ack10-HIST2H3A [nucleoplasm]

Me2K5,Me2aR3-HIST2H3A [nucleoplasm]

Me2K-10-HIST2H3A [nucleoplasm]

p-T12-HIST2H3A [nucleoplasm]

p-T12,MeK-HIST2H3A [nucleoplasm]

Me3K-10-HIST2H3A [nucleoplasm]

p-T12, Me2K-10-HIST2H3A [nucleoplasm]

Me3K5-HIST2H3A [nucleoplasm]

HIST2H3A [nucleoplasm]

Me3K-28-HIST2H3A [nucleoplasm]

Me2K5-HIST2H3A [nucleoplasm]

Inferred To

phospho-H3C13 [nucleoplasm] (Canis familiaris)

phospho-H3-VII [nucleoplasm] (Gallus gallus)

phospho-Hist2h3c2 [nucleoplasm] (Rattus norvegicus)

phospho-H3c4 [nucleoplasm] (Mus musculus)

phospho-p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Danio rerio)

phospho-p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Sus scrofa)

phospho-p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 10

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Name

O-phospho-L-threonine at 12

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_066403.2, NP_001116847.1, NP_001005464.1

Target Pathogen

57c0ab45be737e1cc0a9d2f0, 57c5e634be737e5a0cb4cb11, 57c5eaa7be737e5a0cb4f982, 5b2801b3be737e35a6deea80, 57cdcfdfbe737e0b49b9a3bb, 5b2801b2be737e35a6dea64d, 57c08b76be737e1cc0a95c6a, 5b2801b3be737e35a6df0ddc, 5b2801b3be737e35a6df0ac2, 5b2801b3be737e35a6df0c8a, 5b2801b3be737e35a6df1873, 5b354852be737e166372eaa9, 5b354852be737e166372e85a, 5b2801b2be737e35a6de88ae, 5b2801b2be737e35a6dea9b5, 57c0ab9bbe737e1cc0a9d7f0, 5b2801b3be737e35a6dee562, 5b354852be737e166372e957, 5b2801b2be737e35a6de9484, 5b354852be737e166372eb9b, 5b354852be737e166372eaa2, 57c0aa24be737e1cc0a9c2e3, 5b2801b2be737e35a6dea8d6

OpenTargets

ENSG00000203852

GeneCards

Q71DI3

HPA

ENSG00000203811-HIST2H3C, ENSG00000183598-HIST2H3D, ENSG00000203852-HIST2H3A

Ensembl

ENSP00000385479, ENST00000403683, ENST00000331491, ENSG00000183598, ENSP00000333277, ENSP00000358154, ENSG00000203852, ENSG00000203811, ENST00000369158

PRO

Q71DI3

PDB

5B40, 2X4W, 6T79, 5CIU, 7BU9, 4MZG, 6X5A, 3R93, 4MZH, 4OUC, 2IIJ, 5B0Z, 6T7D, 6FML, 6X59, 3DB3, 4MZF, 3MO8, 6ACE, 5B0Y, 6T7C, 3QO2, 7JOA, 6T7B, 7BQZ, 2X4Y, 7JO9, 6XJD, 5BO0, 6T7A, 2X4X, 6Y5E, 3AV1, 6Y5D, 5VAC

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.704	4
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.576	4
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.576	5
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
UniProt:P29474 NOS3	7	MyrG-NOS3 [Golgi membrane] (R-HSA-534995) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) NOS3 [cytosol] (R-HSA-202114) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139)	0.556	3
UniProt:P14136 GFAP	3	GFAP [lysosomal membrane] (R-HSA-9625195) p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3

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