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p-T816-PKN2 [cytosol]
Stable Identifier
R-HSA-5623652
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-T816-PRK2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Homo sapiens)
p-T816-PKN2 [cytosol] (Homo sapiens)
p-T816-PKN2 phosphorylates AKT1 on serine-308 (Homo sapiens)
p-T816-PKN2 [cytosol] (Homo sapiens)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Homo sapiens)
p-T816-PKN2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)
p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] (Homo sapiens)
p-T816-PKN2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16513 PKN2
Gene Names
PKN2, PRK2, PRKCL2
Chain
chain:1-984
Reference Genes
BioGPS Gene:5586 PKN2
COSMIC (genes):PKN2 PKN2
CTD Gene:5586 PKN2
dbSNP Gene:5586 PKN2
ENSEMBL:ENSG00000065243 PKN2
HGNC:9406 PKN2
KEGG:hsa:5586 PKN2
Monarch:5586 PKN2
NCBI Gene:5586 PKN2
OMIM:602549 PKN2
UCSC:Q16513 PKN2
Reference Transcript
RefSeq:NM_006256.3 PKN2
RefSeq:NM_001320708.1 PKN2
RefSeq:NM_001320709.1 PKN2
RefSeq:XM_011541772.2 PKN2
RefSeq:NM_001320707.1 PKN2
Other Identifiers
11724840_at
11724841_a_at
11758207_s_at
16666896
199_s_at
210969_3p_at
210969_PM_at
210969_at
212628_PM_at
212628_at
212629_PM_s_at
212629_s_at
2345621
2345622
2345623
2345624
2345633
2345634
2345642
2345647
2345649
2345650
2345651
2345652
2345655
2345656
2345657
2345665
2345666
2345667
2345668
2345669
2345670
2345671
2345672
2345673
2345675
2345676
2345677
2345680
2345687
2345690
2345691
2345693
2345697
2345698
2345699
2345700
2345701
2345702
2345703
2345704
2345705
2345706
2345708
2345711
2345713
2345715
3140847
3590502
36835_at
54121_at
55492_at
5586
7902822
A_14_P100308
A_14_P105176
A_14_P113677
A_23_P23227
A_24_P387869
A_32_P226918
A_33_P3242829
A_33_P3242833
GE59090
GO:0003723
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006915
GO:0007155
GO:0007165
GO:0010631
GO:0012501
GO:0016020
GO:0016301
GO:0016604
GO:0016740
GO:0030027
GO:0030030
GO:0030496
GO:0031267
GO:0032154
GO:0032467
GO:0032991
GO:0034330
GO:0035556
GO:0042826
GO:0042995
GO:0043226
GO:0043296
GO:0043297
GO:0045070
GO:0045111
GO:0045296
GO:0045931
GO:0048471
GO:0048870
GO:0051301
GO:0070063
GO:0070161
GO:0106310
GO:0140096
GO:2000145
HMNXSV003045848
HMNXSV003048860
Hs.69171.2.S1_3p_a_at
Hs.69171.2.S2_3p_at
ILMN_1706825
PH_hs_0004094
TC01000831.hg
U33052_s_at
g6650823_RC_3p_a_at
g6650823_RC_3p_at
Participates
as an output of
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Homo sapiens)
as a member of
p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] (Homo sapiens)
Other forms of this molecule
PKN2 [cytosol]
Inferred To
phospho-PKN2 [cytosol]
(Gallus gallus)
phospho-p-T816-PKN2 [cytosol]
(Bos taurus)
phospho-p-T816-PKN2 [cytosol]
(Caenorhabditis elegans)
phospho-p-T816-PKN2 [cytosol]
(Canis familiaris)
phospho-p-T816-PKN2 [cytosol]
(Danio rerio)
phospho-p-T816-PKN2 [cytosol]
(Dictyostelium discoideum)
phospho-p-T816-PKN2 [cytosol]
(Drosophila melanogaster)
phospho-p-T816-PKN2 [cytosol]
(Mus musculus)
phospho-p-T816-PKN2 [cytosol]
(Rattus norvegicus)
phospho-p-T816-PKN2 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T816-PKN2 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T816-PKN2 [cytosol]
(Sus scrofa)
phospho-p-T816-PKN2 [cytosol]
(Xenopus tropicalis)
Homologues of p-T816-PKN2 [cytosol]
(Dictyostelium discoideum)
Homologues of p-T816-PKN2 [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-threonine at 816
Coordinate
816
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001307637.1
,
NP_006247.1
,
NP_001307638.1
,
NP_001307636.1
,
XP_011540074.1
ZINC - World Drugs
PKN2_HUMAN
Guide to Pharmacology - Targets
1521
OpenTargets
ENSG00000065243
ENSEMBL
ENST00000370521
,
ENSP00000359552
,
ENST00000370513
,
ENSP00000359544
ZINC - FDA approved
PKN2_HUMAN
ZINC - Substances
PKN2_HUMAN
ZINC - Biogenic
PKN2_HUMAN
ZINC target
Q16513
PRO
Q16513
GlyGen
Q16513
PDB
4RRV
,
4CRS
,
6GBE
,
6CCY
ZINC - Investigational
PKN2_HUMAN
IntEnz
2.7.11.13
HPA
ENSG00000065243-PKN2
Pharos - Targets
Q16513
ZINC - Predictions - Purchasable
PKN2_HUMAN
HMDB Protein
HMDBP01198
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O92972-PRO_0000278753
0.668
7
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
0.643
4
UniProt:P41208 CETN2
3
CETN2 [cytosol]
(R-HSA-380298)
CETN2 [nucleoplasm]
(R-HSA-4570490)
polySUMO2,3-CETN2 [nucleoplasm]
(R-HSA-4570486)
0.604
3
UniProt:Q12923 PTPN13
2
PTPN13 [nucleoplasm]
(R-HSA-9008915)
PTPN13 [plasma membrane]
(R-HSA-8870318)
0.602
4
UniProt:O76075 DFFB
2
DFFB [cytosol]
(R-HSA-211211)
DFFB [nucleoplasm]
(R-HSA-211195)
0.527
2
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.527
3
UniProt:P0DN37 PAL4G
0.527
2
UniProt:Q12798 CETN1
7
PolyUb-Misfolded CETN1 [late endosome lumen]
(R-HSA-9659982)
CETN1 [cilium]
(R-HSA-9639700)
Misfolded CETN1 [cilium]
(R-HSA-9639714)
Misfolded CETN1 [cytosol]
(R-HSA-9640113)
Ub-Misfolded CETN1 [cytosol]
(R-HSA-9641110)
PolyUb-Misfolded CETN1 [cytosol]
(R-HSA-9641126)
PolyUb-Misfolded CETN1 [lysosomal lumen]
(R-HSA-9659990)
0.527
4
UniProt:Q9UL42 PNMA2
0.527
3
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
UniProt:P47929 LGALS7
1
LGALS7 [cytosol]
(R-HSA-9861116)
0.527
2
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