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PROCR [plasma membrane]
Stable Identifier
R-HSA-5591027
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Endothelial protein C receptor, EPCR_HUMAN, EPCR, activated protein C receptor
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
PROCR:Protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Activated protein C is released from PROCR (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
Activated protein C:PROCR binds F2R (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
PROCR:Activated protein C:F2R [plasma membrane] (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
PROCR:Protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
PROCR binds Protein C (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
PROCR:Protein C [plasma membrane] (Homo sapiens)
PROCR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UNN8 PROCR
Gene Names
PROCR, EPCR
Chain
signal peptide:1-17, chain:18-238
Reference Genes
BioGPS Gene:10544 PROCR
COSMIC (genes):PROCR PROCR
CTD Gene:10544 PROCR
dbSNP Gene:10544 PROCR
ENSEMBL:ENSG00000101000 PROCR
HGNC:9452 PROCR
KEGG:hsa:10544 PROCR
Monarch:10544 PROCR
NCBI Gene:10544 PROCR
OMIM:600646 PROCR
UCSC:Q9UNN8 PROCR
Reference Transcript
RefSeq:NM_006404.4 PROCR
Other Identifiers
10544
11737798_a_at
16913065
203650_PM_at
203650_at
3883214
3883215
3883216
3883217
3883218
3883219
3883221
3883222
3883223
3883224
3883232
647_at
8062108
A_23_P80040
GE53679
GO:0005515
GO:0005576
GO:0005615
GO:0005813
GO:0005815
GO:0005886
GO:0005925
GO:0007596
GO:0009986
GO:0016020
GO:0038023
GO:0043226
GO:0048471
GO:0050819
GO:0060089
GO:0070062
HMNXSV003004705
HMNXSV003022864
ILMN_1717262
L35545_at
PH_hs_0004716
PH_hs_0035477
TC20000248.hg
g5453645_3p_at
Participates
as an output of
Activated protein C is released from PROCR (Homo sapiens)
as an input of
PROCR binds Protein C (Homo sapiens)
as a component of
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
PROCR:Protein C [plasma membrane] (Homo sapiens)
Other forms of this molecule
PROCR(18-?) [extracellular region]
Inferred To
Procr [plasma membrane]
(Mus musculus)
Procr [plasma membrane]
(Rattus norvegicus)
PROCR [plasma membrane]
(Bos taurus)
PROCR [plasma membrane]
(Canis familiaris)
PROCR [plasma membrane]
(Gallus gallus)
PROCR [plasma membrane]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000216968
,
ENSP00000216968
OpenTargets
ENSG00000101000
HPA
ENSG00000101000-PROCR
PRO
Q9UNN8
Pharos - Targets
Q9UNN8
GlyGen
Q9UNN8
Orphanet
PROCR
PDB
1LQV
,
7OKU
,
1L8J
,
7OKS
,
6SNY
,
7OKV
,
7OKT
,
7Q5D
,
3JTC
,
8C44
,
4V3E
,
4V3D
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25116 F2R
4
F2R(27-41) [extracellular region]
(R-HSA-114586)
pro-F2R [plasma membrane]
(R-HSA-9708861)
Activated F2R [plasma membrane]
(R-HSA-114531)
F2R(27-425) [plasma membrane]
(R-HSA-61309)
0.641
5
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.527
2
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